卡铂多相脂质体对移植U_（14）腹水瘤小鼠生存期的影响

将小鼠宫颈癌瘤株１４号（Ｕ１４）移植至Ｋｍ小鼠腹腔形成腹水瘤模型并随机分为３组。脂质体组一次性腹腔注射卡铂多相脂质体１．５ｍｇ／０．７５ｍｌ，水剂组一次性腹腔注射卡铂水剂１．５ｍｇ／０．７５ｍｌ，对照组腹腔注射０．７５ｍｌ生理盐水。结果表明，对照组自移植后第５天开始死亡，平均生存９．８６天；水剂组第８天开始死亡，平均生存１１．４３天；脂质体组第１０夫开始死亡，平均生存１４．１４天。脂质体组与对照组生存期比率（Ｔ／Ｃ）为１４３．４１％（Ｐ＜０．０２５），接近显效标准；水剂组Ｔ／Ｃ为１１５．９２％（Ｐ＞０．２），未达有效标准。用药７天后脂质体组小鼠腹围增长率与其它两组比较为最低。提示卡铂多相脂质体腹腔注射对小鼠腹腔内移植瘤抑制作用明显，能显著延长荷瘤小鼠的寿命。

Intraperitoneal administration of carboplatin polyphase liposome affect the survival time of mice transplanted with U_(14) ascites tumor cells.

An ascitic tumor model was established with the mouse uterine cervix cancer No.14 cell transplanted intraperitoneally to twenty one Km mice which were divided into three groups at random.1 . 5mg/0 . 75ml carboplatin encapsulated in polyphase liposome was injected into the peritoneal cavity of each mouse of the liposome group and 1 . 5mg/0 . 75ml carboplatin aqueous solution was injected into that of the aqueous group.The mice of the control group were only injected with normal saline solution.The shortest survival time of mouse in control group was 5 days after transplantation and the mean survival time was 9 .86 days.The shortest survival time of mouse in the liposome group was 10 days and mean survival time was 14 days . The T/C(treatment : control)was 143.41% ( P<0.025 ) which almost reached the standard of obvious effect.However in the aqueous group, T/C was only 115.92%( P>0.2 ) which was even below the standard of effect.The results of this study suggest that the carboplatin encapsulated in polypliase liposomes is more effective in suppressing the multiplication of the ascitic tumor cells in the peritoceal cavity than that of the carboplatin aqueous solution.