无环鸟苷抑制小鼠单纯疱疹性角膜炎潜伏病毒激活作用的研究

目的 证实无环鸟苷能够作用于潜伏单郊病毒的激活阶段，抑制病毒活化。方法 以Ｂａｌｂ／ｃ小鼠作为潜伏感染模型，以紫外线Ｂ照射为激活条件，治疗组给予无环鸟苷口服，停药后１天处死动物检测活化病毒。结果 治疗组３０例中无１例，而对照组３０例中有１２例检测出活化病毒（Ｐ〈０．０１）；治疗至照射后２天的１０只鼠无１例，而相应对照组１０只中６例检出活化病毒（Ｐ〈０．０１）。结论 预防性应用ＡＶＣ特异作用于病毒激活期，有效的抑制病毒活化。

Inhibition of Latent Virus Reactivation by Acyclovir in Murine Herpes Simplex Keratitis

ObjectiveTo determine that prophylactic oral acyclovir can particularly effective at the reactivation period of herpes simplex virus type 1(HSV 1).MethodsLatent infection with HSV 1 was established in 60 Balb/c mice. 30 of them were given acyclovir(ACV) on 2,3,4 d respectively,after UV B radiation and killed 1 d after the end of ACV used,30 serving as control were killed at the same time with corresponding ACV group.Cornea and trigeminal ganglia were removed to detect reactivated virus.ResultsNone of the 30 received ACV and 12 of the 30 control showed virus( P <0 01).None of the 10 received ACV on 2 d after radiation and 6 of the 10 corresponding control showed virus( P <0 01).It showed that the viral reactivation was effectively inhibited in ACV group.ConclusionProphylactic ACV particularly acts at the reactivate period,and can effectively reduce the latent viral reactivation in herpes simplex keratitis.