2型糖尿病患者遗传性病例对照研究

目的 通过对2型糖尿病一级亲属患病率和遗传度的分析,探讨遗传因素在2型糖尿病中的作用。方法 采用病例对照方法,选择沈阳市2所医院门诊与住院的2型糖尿病患者203例作为病例组,同期选取社区健康人群201人作为对照组进行调查。采用χ²检验进行统计分析,并用Falconer法计算遗传度。结果 家族史是2型糖尿病的危险因素(OR=5.89);病例组一级亲属的2型糖尿病患病率为6.76%,显著高于对照组的1.27%,相对危险度为5.32(95%CI=3.54~7.99);2型糖尿病一级亲属的遗传度为56.88%。结论 遗传因素在2型糖尿病的发生中起重要作用,其一级亲属对糖尿病的遗传易感性较高,是糖尿病预防和控制的重点人群。

Case-control study on genetic factors of type 2 diabetes mellitus

Objective To study the prevalence rate and heritability in the first degree relatives of type 2 diabetes mellitus (DM)in Shenyang,to estimate the effect of genetic factors in type 2 diabetes mellitus.Methods On the basis of the survey of type 2 diabetes mellitus in hospital population and urban community population of Shenyang(203 cases and 201 controls),a case-control study was carried out.Chi square test was used for data analysis and the Falconer was used to calculate the heritability.Results The family history was the risk factor of type 2 diabetes mellitus(OR=5.89).The prevalence rate in the first degree relatives of index cases was 6.76%,higher than the controls of 1.27%,the risk ratio(RR)was 5.32(95% CI=3.54~7.99,).The heritability was 56.88%.Conclusion Genetic factors make an important role in type 2 diabetes mellitus,and higher genetics susceptibility were found in the first degree relatives of DM,on whom prevention and treatment for DM should be focused.