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Bizarre and scary ECG in yew leaves poisoning: Report of successful treatment
Authors:Natascia Cerrato MD  Pietro Tizzani MD  Emma Actis Perinetto MD  Antonio Dellavalle MD  Enzo Aluffi MD
Affiliation:1. Division of Cardiology, Ospedale San Lazzaro, Alba, CN, ItalyThe first two authors contributed equally to the paper.;2. Emergency Department, Ospedale San Lazzaro, Alba, CN, Italy;3. Division of Cardiology, Ospedale San Lazzaro, Alba, CN, Italy
Abstract:Yew leaves poisoning is a rare life‐threatening intoxication, whose diagnosis can be difficult. Initial symptoms are nausea, vomiting, abdominal pain, dizziness, tachycardia, muscle weakness, confusion, beginning within 1 hr from ingestion and followed by bradycardia, ventricular arrhythmias, ventricular fibrillation, severe hypotension, and death. Taxine‐derived alkaloids are responsible for the toxicity of the yew leaves, blocking sodium and calcium channels, and causing conduction abnormalities. Because of lack of a specific antidote and limited efficacy of common antiarrhythmic drugs, prompt diagnosis, detoxification measures, and immediate hemodynamic support (also with transvenous cardiac stimulation) are essential.
Keywords:poisoning  taxine  ventricular arrhythmias  yew leaves
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