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Identification of novel translocation between short arm of chromosome 4 and long arm of chromosome 6 in an infertile man using Interphase Chromosome Profiling (ICP) |
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| Authors: | S. Kaul H. Kaur S.K.S. Vats J. Chawla R. Jindal P. Khetarpal |
| Affiliation: | 1. Centre for Human Genetics and Molecular Medicine, School of Health Science, Central University of Punjab, Bathinda, India;2. Adesh University, Bathinda, India;3. Dss Imagetech Pvt. ltd, New Delhi, India;4. Jindal Heart Hospital, Jindal heart institute and IVF centre, Bathinda, India |
| Abstract: | Conventional cytogenetics has always been a favourite to detect chromosomal aberrations. Carriers of chromosomal translocation are often phenotypically normal but are infertile. Couples are often advised to go for karyotyping, but culture failure or improper metaphase spread with poor banding often makes the analysis difficult. We report here a novel translocation between short arm of chromosome 4 and long arm of chromosome 6 in an infertile man using an advanced molecular cytogenetic technique of Interphase Chromosome Profiling (ICP). |
| Keywords: | chromosome translocation infertility interphase chromsome profiling |