基于骨和无有机成分骨与羟基磷灰石压缩性能实验比较的强度分析

目的分析判定以珊瑚为基体,通过水热交换法制成的羟基磷灰石植入体内后的强度是否可以达到活体骨的水平。方法实验测量羟基磷灰石、含有机成分的骨、无有机成分的骨的压缩极限应力。通过对比羟基磷灰石、骨及无有机成分的骨的压缩强度差别,确定胶原纤维对骨压缩强度的作用,进而应用经验模型预估人造羟基磷灰石在一定空隙度(0.1～0.5)范围变化时的强度。结果羟基磷灰石、骨及无有机成分的压缩强度分别为14.1 GPa、207 GPa和31.7 GPa。结论去除骨中的有机成分后其压缩强度降低约80%。水热交换法制成的羟基磷灰石抗压强度可能高于骨内羟基磷灰石,这种骨替代材料植入体内后,随着骨和纤维组织在内部生长,其强度有可能达到活体骨的水平。

Estimating compressive strength of hydroxyapatite based on comparison to tested strength of bone,bone without collagens and hydroxyapatite

Objective To estimate whether the implanted coralline hydroxyapatite(CHA) prepared by hydrothermal conversion of coral can reach the level of compressive strength of bone in vivo, because CHA could be implanted in human body directly and then make the bone tissues grow into their porous structure, which will reinforce their strength.Methods The compressive strengths of CHA, bone with and without collagens are measured respectively to determine the enhancement of collagen to compressive strength of bone.Based on the test results, a typical model for predicting the variation of strength of porous bioceramic with porosity is employed to estimate the compressive strength of CHA with porosity from 0.1 to 0.5.Results The compressive strengths achieved by CHA, bone with and without collagens are 14.1GPa, 207 GPa and 31.7 GPa respectively.Conclusion The compressive strength of bone would decrease 80% after its collagens are eliminated.The strength of CHA may be stronger than that of hydroxyapatite in bone, and its final strength could be able to reach the level of bones with the bone tissue grow up.