微量低分子肝素钙在严重创伤非显性DIC的临床研究

目的：评价微量低分子肝素钙治疗严重创伤非显性DIC的疗效.方法：将44例严重创伤非显性DIC患者随机分为两组, 治疗组和对照组各22例.两组均采用综合治疗,治疗组早期加用低分子肝素钙,24 h用药量0.2～ 0.3 mg/（k g·d）,连用3 d.比较两组伤口渗血发生率、DIC发生率及病死率,观察治疗组应用微量肝素前后BPC、PT、APTT变化情况.结果：与对照组比较,治疗组DIC发生率、病死率明显降低（P均＜0.01）,伤口渗血发生率减少（P＜0.05）;治疗组应用微量肝素后,BPC升高（P＜0.05）,APTT、PT差异无显著性（P＞0.05）.结论：应用低分子肝素钙能有效地防止严重创伤非显性DIC向DIC的发展,并能降低病死率.

Clinical Study on Microdosage Low Molecular Weight Heparin in Severe Trauma Patients with Prophase State of Disseminated Intravascular Coagulation

Objective:To investigate the therapeutic effect of microdosage low molecular weight heparin(LMWH) therapy in Severe Trauma patients with disseminated intravascular coagulation prophase state(pro-DIC).Methods: Forty-four severe trauma patients in disseminated intravascular coagulation prophase state were randomly divided into routine treatment group(n=22,given microdosage LMWH,twice a day for 3 days,besides routine treatment) and control group(n= 22,routine treatment).The incidence of DIC and mortality in two groups were observed and compared.Results: Incidence of DIC and mortality in treatment group were significant lower than those in control group(P<0.01).Conclusion: Microdosage LMWH is applied early in severe trauma patients in disseminated intravascular coagulation prophase state,which could not only prevent efficiently DIC,but also diminish mortality.