p53 protein accumulation, iodine-unstained lesions, and alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese alcoholic men with esophageal dysplasia |
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Authors: | Yokoyama Akira Tanaka Yoichi Yokoyama Tetsuji Mizukami Takeshi Matsui Toshifumi Maruyama Katsuya Omori Tai |
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Institution: | National Hospital Organization, Kurihama Alcoholism Center, Kanagawa, Japan. a_yokoyama@kurihama1.hosp.go.jp |
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Abstract: | Inactive heterozygous aldehyde dehydrogenase-2 (ALDH2(*)1/(*)2) and less-active alcohol dehydrogenase-1B (ADH1B(*)1/(*)1) increase the risk of esophageal cancer in East Asian drinkers, and esophageal cancer multiplicity is strongly associated with ALDH2(*)1/(*)2. p53 alterations are key molecular events in multifocal carcinogenesis in the esophagus. We studied 260 esophageal-cancer free Japanese alcoholics with esophageal dysplasia diagnosed by biopsy of distinct iodine-unstained lesions (DIULs) ≥5mm. The degree of p53 protein accumulation was positively associated with the degree of atypia (p<0.0001) and size (p=0.040) of DIULs and with the presence of multiple DIULs (p=0.070), but not with ALDH2(*)1/(*)2 or ADH1B(*)1/(*)1. |
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Keywords: | Alcohol Alcohol dehydrogenase-1B Aldehyde dehydrogenase-2 Esophageal dysplasia p53 |
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