The metabolic syndrome: Insulin resistance |
| |
Authors: | Nasser Mikhail |
| |
Institution: | (1) MSc Division of Endocrinology, Department of Medicine, Olive-UCLA Medical Center, 14445 Olive View Drive, Sylmar, CA 91342, USA |
| |
Abstract: | Insulin resistance is the most accepted unifying theory explaining the pathophysiology of the metabolic syndrome. However,
epidemiologic studies indicate that a substantial proportion of patients with the metabolic syndrome do not have evidence
of insulin resistance, and the correlation between insulin resistance and individual components of the syndrome is weak to
moderate. Insulin resistance may play an important role in the development of hyperglycemia and dyslipidemia, which can further
aggravate insulin resistance. The implication of insulin resistance in hypertension appears to be less strong than its role
in causing hyperglycemia and dyslipidemia. Obesity may be another pathogenic factor in the metabolic syndrome that may help
initiate or worsen insulin resistance. However, like insulin resistance, obesity is not universal in the metabolic syndrome,
and many obese subjects do not have metabolic abnormalities. This review provides an update on the relationship between insulin
resistance and main components of the metabolic syndrome: hyperglycemia, dyslipidemia, hypertension, and obesity. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|