77例儿童恶性肿瘤停药后脏器功能随访报告

目的了解化疗对恶性肿瘤患儿各主要脏器功能的影响。方法对77例停药患儿进行了造血功能、肝、肾、心功能、电解质及钙磷代谢、免疫功能及甲状腺功能检测。结果77例恶性肿瘤患儿平均停药3年（2月-10年）其造血、肝、肾、心、免疫、甲状腺功能及电解质等多数指标在正常范围内，提示各重要脏器未见明显损害，且不同类别肿瘤脏器功能损害也无明显差异。结论本中心现行的化疗方案是安全可靠的，对患儿的重要脏器功能无明显影响。但需进一步延长观察时间，扩大样本量并尽可能选择更灵敏的检测指标。

Function of viscera following cease of anticarcinogenic treatment in 77 childhood cases with malignant tumors

Objective To analysis the effect of chemotherapy on vital viscera in childhood malignant tumors. Methods Measurement of function of hematopoietic organ, liver, kidney and heart immunology and thyroid grand and detection of level of electric elements in serum and metabolism of calcium and phosphate in 77 childhood cases with malignant tumors. Results The average period of cease of anticarcinogenic treatment was 3 years(2 months to 10 years). Most of indicators of function were showed in normal limit for hematopoietic, liver, kidney, heart, immunology and thyroid grand as well as level of electric elements in serum in 77childhood cases with malignant tumors. All the results suggested that there were no obvious damage in function of vital viscera and no plain differences among various kinds of tumors. Conclusion The current scheme of anticarcinogenic treatment performed in our center showed safety and reliability without obvious damage in function of vital viscera as well. It is needed that further prolonged the following time, expended the samples and selected more sensitive laboratory indicators.