Recurrent ovarian carcinoma: retreatment utilizing combination chemotherapy including cis-diamminedichloroplatinum in patients previously responding to this agent |
| |
| Authors: | V Seltzer S Vogl B Kaplan |
| |
| Affiliation: | 1. Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, 1300 Morris Park Avenue, Bronx, New York 10461 U.S.A.;2. Department of Medicine, Division of Medical Oncology of the Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461 U.S.A. |
| |
| Abstract: | Eleven women with advanced ovarian cancer treated postoperatively with combination chemotherapy (cytoxan, hexamethylmelamine, Adriamycin, and cis-platinum) had disease-free intervals of 5 to 46 months (mean: 22 months) and subsequently developed recurrent carcinoma. Each patient was then retreated with combination chemotherapy which included cis-platinum. There was a 72% response rate to retreatment (36% complete, 36% partial). These overall and complete remission rates are comparable to those of platinum-based combination chemotherapy in patients without prior treatment. Those patients who responded to retreatment had a significantly longer mean survival rate than those who did not. |
| |
| Keywords: | To whom reprint requests should be addresssed at: Department of Obstetrics and Gynecology Queens Hospital Center 82-68 164th Street Jamaica N.Y. 11432. |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
