| 恶性肿瘤组织CD8~+/CD28~+细胞表达与细胞凋亡的相关性 |
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| 引用本文： | 夏欣一,吴永明,潘连军,黄宇烽,周振英.恶性肿瘤组织CD8~+/CD28~+细胞表达与细胞凋亡的相关性[J].肿瘤防治研究,2006,33(9):656-658. |
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| 作者姓名： | 夏欣一 吴永明 潘连军 黄宇烽 周振英 |
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| 作者单位： | 南京军区南京总医院解放军临床检验医学研究所; 江苏省肿瘤防治研究所分子生物学研究室; |
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| 摘 要： | 目的探讨恶性肿瘤组织中CD8+/CD28+细胞杀伤肿瘤细胞的机制。方法用流式细胞术检测恶性肿瘤组织中CD8+/CD28+细胞表达率及细胞凋亡(APO)水平,并分析两者之间的关系。结果恶性肿瘤组织的CD8+/CD28+细胞检出率为(6.86±4.19)%,显著低于正常对照组织(11.85±3.80)%(P<0.01)。恶性肿瘤组织APO检出率为(1.49±1.24)%,显著低于正常对照组织(4.34±3.28)%,(P<0.01)。在恶性肿瘤组织中,CD8+/CD28+细胞检出率和APO表达水平呈显著正相关(r=0.5995,P<0.01)。结论恶性肿瘤能引起组织中CD8+/CD28+细胞表达率和APO检出率显著下降,且二者检出率呈显著正相关。恶性肿瘤组织中CD8+/CD28+细胞杀伤肿瘤细胞的机制可能与诱导肿瘤细胞凋亡密切相关。
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| 关 键 词： | 流式细胞术 恶性肿瘤 T细胞 细胞凋亡 |
| 文章编号： | 1000-8578（2006）09-0656-03 |
| 收稿时间： | 2005-08-01 |
| 修稿时间： | 2005-08-012005-09-30 |
Correlation between CD8+/CD28+ Cell Expression and Apoptosis in Malignant Tumor Tissue of Patients with Malignant Tumor |
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| XIA Xin-yi,WU Yong-ming,PAN Lian-jun,HUANG Yu-feng,ZHOU Zhen-ying.Correlation between CD8+/CD28+ Cell Expression and Apoptosis in Malignant Tumor Tissue of Patients with Malignant Tumor[J].Cancer Research on Prevention and Treatment,2006,33(9):656-658. |
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| Authors: | XIA Xin-yi WU Yong-ming PAN Lian-jun HUANG Yu-feng ZHOU Zhen-ying |
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| Institution: | 1. Institute of Clinical Laboratory Medicine; PLA; Nanjing General Hospital of Nanjing Command; Nanjing 210002; China; 2. Molecular Biology Laboratory; Jiangsu Institute of Cancer Research; |
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| Abstract: | Objective To study the correlation between CD8 +/CD28 + cell and APO expression level in malignant tumor tissue on patients with malignant tumor. Methods CD8 +/CD28 + cells and APO cells percentage were measured in malignant tumor tissue from 190 patients with malignant tumor by flow cytometry. The correlation was analyzed between CD8 +/CD28 + cells and APO percentage. Results CD8 +/CD28 + cells and APO cells percentage of malignant tumor tissue were lower than those of normal control tissue (6.86±4.19)%, (... |
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| Keywords: | Flow cytometry Malignant tumor T lymphocyte Cell apoptosis |
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