Survivin、VEGF在脑膜瘤中的表达及其与肿瘤血管形成的关系

目的探讨凋亡抑制基因Survivin、血管内皮生长因子（VEGF）、微血管密度（MVD）在脑膜瘤中的表达及临床意义。方法采用免疫组化SP法，对72例人脑膜瘤和15例非肿瘤脑组织的Survivin蛋白、VEGF和MVD值进行测定，Survivin、VEGF的表达用评分表衡量。结果Survivin、VEGF在人脑膜瘤中的表达（平均染色强度分别为3．6±3．2、3．2±2．6）均显著高于在非肿瘤脑组织中的表达（平均染色强度分别为0、0．4±0．3），并且随着肿瘤恶性程度的增高而增高；在肿瘤组织中Survivin和VEGF值呈正相关（r=0．287，P〈0．05）；两者的高表达具有促进肿瘤新生血管形成的作用，MVD则是血管形成的量化指标。Survivin和VEGF高表达与脑膜瘤侵袭性关系密切。结论Survivin、VEGF的过度表达在脑膜瘤的发生、发展中起重要作用，是肿瘤血管快速生成的关键因素；并且可作为判断脑膜瘤侵袭性和评估预后的良好生物学指标。

Expression of Survivin and VEGF in meningioma and its relationship with angiogenesis

Objective To investigate the expression of Survivin, vascular endothelial growth factor （VEGF） and microvessel density （MVD） in meningioma and its significance. Methods The Survivin, VEGF and MVD were examined by immunohistochemical stain in 72 brain meningioma tissues and 15 non-tumor brain tissues. Survivin and VEGF of expression to be measured by score table. Results Tile expression of Survivin and VEGF in meningioma tissues （ average 3.6 ± 3.2/3.2 ±2. 6 ） was significantly higher than that in non-tumor brain tissues （ average 0/0. 4± 0. 3 ）, and it increased parallel with the elevation of malignant degree. Meningioma, there was appositive correlation between Survivin and VEGF （ r = 0. 287,P 〈 0. 05 ）. Their high expression is the promotion of tumor angiogenesis, MVD is the quantitative indicators of angiogenesis. Its high expression was positively correlated with the invasive tumor （P 〈 0. 05 ）. Conclusions The overexpression of Survivin and VEGF associated with the occurrence and development of meningioma, and it contributes to tumor angiogenesis. Survivin, MVD, VEGF can be used as a good biological indicators in meningioma invasive and assessment of the prognosis.