Emerging concepts for the mechanism of alcoholic pancreatitis from experimental models |
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Authors: | Stephen J. Pandol Ilya Gukovsky Akihiko Satoh Aurelia Lugea Anna S. Gukovskaya |
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Affiliation: | (1) Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Building 258, Room 340, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA;(2) Department of Medicine, University of California, Los Angeles, CA, USA;(3) USC-UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Los Angeles, CA, USA |
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Abstract: | The pathophysiologic mechanisms that underlie acute and chronic pancreatitis arising from alcohol abuse are poorly understood. The reasons for this state of knowledge result historically from a lack of models for experimental investigation. Ethanol feeding alone, even at high doses, has minimal and inconsistent effects on morphologic findings in the pancreas in experimental animals. This experience, plus the fact that alcohol abuse causes pancreatic pathology in only a minority of patients, suggest that ethanol acts to sensitize the pancreas to the deleterious effects of other stimuli. In this article, we discuss findings to support this concept of ethanol as a sensitizing agent and experimental models developed that can be used to investigate the effects of ethanol on the pathologic processes of pancreatitis. These pathologic processes include inflammation, cell death, intrapancreatic digestive enzyme activation, and fibrosis. |
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Keywords: | alcohol pancreatitis cholecytokinin fatty acid ethyl esters nuclear factor- /content/a2x9k285e1rjfdrk/xxlarge922.gif" alt=" Kgr" align=" BASELINE" BORDER=" 0" >B |
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