HISS与胰岛素抵抗

肝胰岛素敏感性物质(HISS)在胰岛素抵抗的发生机制中起重要作用。近来研究发现,HISS和胰岛素在对餐后血糖的调节作用中占有同等重要地位。HISS由肝脏释放,作用于骨骼肌,促进葡萄糖以糖原形式储存,但对肝、胃、脂肪组织无此作用。凡影响HISS功能的因素,包括肝副交感神经、一氧化氮、谷胱甘肽、饮酒、高糖饮食等均可能引起HISS依赖的胰岛素抵抗。对HISS的研究不仅可加深对胰岛素抵抗发生机制的认识,对其治疗更具有积极的指导意义。

HISS and insulin resistance

Hepatic insulin sensitizing substance(HISS),plays an important role in the pathogenesis of insulin resistance.Recent researches have found that the glucose disposal effect of insulin after a meal is equal to the action of HISS.HISS is released from liver and acts on skeletal muscle but not liver,gut,or adipose tissue to stimulate glucose storage as glycogen.The release of HISS is influenced by hepatic parasympathetic nerves,nitric oxide,hepatic glutathione levels,alcohol and sucrose-rich diets and so on,which can lead to HISS-dependent insulin resistance.Researches on HISS can enhance the understanding of the pathogenesis of insulin resistance,and provide an instructive direction on the management of insulin resistance.