| 膀胱肿瘤患者外周血淋巴细胞p16和cyclin D_1的表达及其临床意义 |
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| 引用本文： | 吴天鹏,张孝斌,熊治国,张杰,程帆,陈立新,. 膀胱肿瘤患者外周血淋巴细胞p16和cyclin D_1的表达及其临床意义[J]. 肿瘤防治研究, 2003, 30(5): 380-381 |
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| 作者姓名： | 吴天鹏 张孝斌 熊治国 张杰 程帆 陈立新 |
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| 作者单位： | 吴天鹏（430060,武汉大学人民医院泌尿外科）;张孝斌（430060,武汉大学人民医院泌尿外科）;熊治国（湖北省肿瘤医院腹泌外科）;张杰（430060,武汉大学人民医院泌尿外科）;程帆（430060,武汉大学人民医院泌尿外科）;陈立新（十堰市太和医院泌外） |
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| 摘 要： | 目的 研究膀胱肿瘤患者外周血中淋巴细胞p16和cyclinD1的表达及其临床意义。方法 应用FCM检测 4 7例膀胱癌及 2 0例对照组的外周血淋巴细胞中 p16和cyclinD1的表达。结果 膀胱癌患者p16和cyclinD1基因蛋白的平均表达率分别为 (2 .4 8± 0 .91) %、(12 .4 8± 9.2 7) %与正常人群的表达率 (7.4 9± 5 .2 2 ) %、(0 .6 6± 0 .5 ) %比较有显著差异 (P <0 .0 1) ;治愈 37例中 p16和cyclinD1的表达率正常 ,而复发者 p16和cyclinD1无一例在正常值以内。结论 外周血淋巴细胞 p16和cyclinD1的异常表达与荷瘤状况有密切关系 ,有望为分子诊断与筛选提供依据 ,并可作为膀胱癌复发的监测指标。
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| 关 键 词： | 蛋白p16 cyclinD1 膀胱肿瘤 外周血 |
| 文章编号： | 1000-8578(2003)05-0380-02 |
| 收稿时间： | 2003-01-22 |
| 修稿时间： | 2003-01-22 |
Expression of p16 and cyclin D1 protein in peripheral blood ofpatients with bladder cancer |
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| WU Tian-peng,ZHANG Xiao-bin,XIONG Zhi-guo,et al. Expression of p16 and cyclin D1 protein in peripheral blood ofpatients with bladder cancer[J]. Cancer Research on Prevention and Treatment, 2003, 30(5): 380-381 |
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| Authors: | WU Tian-peng ZHANG Xiao-bin XIONG Zhi-guo et al |
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| Affiliation: | Department of Urology; Renmin Hospital of Wuhan University; Wuhan 430060; China; |
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| Abstract: | Objective To investigate the expression of p16 and cyclin D_1 protein in peripheral blood of bladder cancer. Methods p16 and cyclin D_1 protein were determined with flow cytometry in 47 cases bladder cancer and 20 cases normal control. Results The levels of p16 were ( 2.48 ± 0.91 )% in cancer group and ( 7.49 ± 5.22 )% in control group. While the levels of cyclin D_1 were ( 12.48 ± 9.27 )% and ( 0.66 ± 0.5 )%. Mean value of p16 in the cancers were lower than that in the controls ( P < 0.01 ),... |
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| Keywords: | Protein p16 cyclin D_1 Bladder cancer Peripheral blood |
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