| Wnt信号通路与神经发生 |
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| 引用本文： | 张建,胡远兵,杨忠,蔡文琴.Wnt信号通路与神经发生[J].解剖科学进展,2005,11(3):258-260,264. |
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| 作者姓名： | 张建 胡远兵 杨忠 蔡文琴 |
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| 作者单位： | 第三军医大学基础部神经生物学教研室,重庆,400038;四川成都武警总队医院内一科 |
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| 基金项目： | 第三军医大学出国人员回国启动基金资助项目 |
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| 摘 要： | W nt通路是细胞增殖分化的关键调控环节,在胚胎发育和肿瘤发生中起着重要作用。W nt途径参与了基因表达调节、细胞迁移粘附、细胞极化等过程,同时还与其它信号通路存在交叉协同。W nt/β-caten in通路在进化过程中高度保守,此通路的主要分子构成及相关调控机制已得到基本阐明。对神经系统而言,已有足够证据显示此通路参与了对神经前体细胞增殖,分化以及决定细胞命运的调控。近年更有研究显示,W nt/β-caten in途径对神经系统的发育包括皮层模式建立,突触形成等也是至关重要的。
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| 关 键 词： | Wnt信号通路 神经发生 β-catenin 细胞增殖分化 基因表达调节 胚胎发育 神经系统 Wnt通路 Wnt途径 |
| 文章编号： | 1006-2947（2005）03-0258-03 |
| 收稿时间： | 2005-04-12 |
| 修稿时间： | 2005-04-12 |
Wnt Pathways and the Neurogenesis |
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| ZHANG Jian,HU Yuan-bing,YANG Zhong,CAI Wen-qin.Wnt Pathways and the Neurogenesis[J].Progress of Anatomical Sciences,2005,11(3):258-260,264. |
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| Authors: | ZHANG Jian HU Yuan-bing YANG Zhong CAI Wen-qin |
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| Abstract: | Wnt pathways play a pivotal role in embryo development and tumorigenesis by modulating cell proliferation and differentiation. They are involved in regulation of gene expression, migration, adhesion and polarity of cells, and usually cooperate with other signaling pathways. The canonical Wnt/β-catenin in the process of development is the best understood and many of the components have been identified. In the past few years, Wnt signaling has been demonstrated to participate in the maintenance of proliferation of neural progenitors and the progenitor cell fate decision. Recent studies indicated that Wnt pathways also implicated in cortex patterning and synapse formation. |
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