人群日本血吸虫病再感染与优势抗体应答的研究

目的 :为研究日本血吸虫病流行区人群中特异性抗体水平是否为再感染的危险因素。方法 :选择江西省新建县鄱阳湖一小岛上三个毗邻的自然村作为观察试区 ,调查 196名 ( 3- 2 5岁 )感染者中 ,吡喹酮治疗后粪检阴性的 138人经过一个感染季节后再感染的情况 ,并检测其血清特异性同型限制性抗体水平。同时就人群接触疫水的暴露水平及年龄因素、血样中特异的同型限制性抗体水平诸因素同再感染的关系进行非条件 logistic回归分析。结果 :虫卵可溶性抗原和粗制成虫抗原特异的 Ig G4抗体水平是再感染发生的危险因素 ,危险度分别是 2 .83和 2 .4 0。结论 :本研究结果可能成为构建对再感染易感状态作预测性诊断试验的基础。

STUDIESON ANTIBODY RESPONSESAND HUMAN SCHISTOSOMIASIS JAPONICA REINFECTION

AIM:To explore if there are some antibody responses to be correlated strongly with susceptibility to reinfection of S.japonicum.METHODS:A group of1 96 individuals aged3 - 2 5 years old in a schistosomiasis endemic area in Nanshan Island of Poyang Lake,who were treated and followed up for identification of reinfection over a1 0 - month period during which intense transmission continued in the study area.Serology for testing isotype- restrict- ed antibody responses quantitatively to SEA and WA was performed according to predeter- mined design in the cohort.RESULTS:After allowing for age and exposure in a logistic re- gression analysis,Ig G4antibodies were significantly related to susceptibility to reinfection. The individuals with high levels of SEA- specific Ig G4and/or WA- specific Ig G4being2 .83 and 2 .40 times were more likely to become reinfected after treatment.CONCLUSION: These findings may form a basis for construction of prognostic tests predicting the probabili- ty of reinfection and targeting treatment leading to a reduction in drug costs of chemothera- py.