Detection of serum hepatitis B, C, and D viral nucleic acids and its implications in hepatocellular carcinoma patients |
| |
Authors: | Yi-Hsiang Huang Jaw-Ching Wu Gar-Yang Chau Shih-Haw Tsay Kuang-Liang King Wen-Yung Sheng Wing-Yiu Lui Shou-Dong Lee |
| |
Affiliation: | (1) Department of Medicine, Division of Gastroenterology, Veterans General Hospital, National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China, TW;(2) Department of General Surgery, Division of Gastroenterology, Veterans General Hospital, National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China, TW;(3) Department of Pathology, Division of Gastroenterology, Veterans General Hospital, National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China, TW |
| |
Abstract: | The association of viremia, elevated serum alanine aminotransferase (ALT) levels, and hepatocyte inflammatory activity in hepatocellular carcinoma (HCC) patients was studied. Serum samples from 114 HCC patients undergoing surgery were assayed for hepatitis B, C, and D viral nucleic acids by polymerase chain reaction (PCR) prior to surgery. Of these patients, 65 had HBV infection alone, 15 had HCV infection alone, 4 had HDV infection, 20 had HBV and HCV superinfection, 1 had triple viral infection, and 9 were negative for HBV and HCV infections. The prevalence of active viral replication was significantly higher in HCV than in HBV (92% versus 70%; P = 0.006) patients, and significantly higher mean serum ALT levels were also noted in the HCV group than in the HBV group (P = 0.02). The incidence of marked ALT elevation (>200 U/l) was highest in the HCV (27%) and the HDV (25%) groups. Patients in the HCV group were 10 years older than those in the HBV group. Viral superinfection did not accelerate the development of HCC. Viral replication persisted in a significant portion of HCC patients and a higher prevalence of hepatic inflammation was noted in patients with HCV- and, possibly, HDV-related HCC. (Received Sept. 22, 1997; accepted Dec. 19, 1997) |
| |
Keywords: | : hepatocellular carcinoma polymerase chain reaction hepatitis B virus hepatitis C virus hepatitis D virus |
本文献已被 SpringerLink 等数据库收录! |
|