Patterns of genotype distribution in multiple human papillomavirus infections. |
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Authors: | L H S Oliveira M L G Rosa S M B Cavalcanti |
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Institution: | Department of Microbiology and Parasitology, Fluminense Federal University, Niterói, RJ, Brazil. mipledy@centroin.com.br |
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Abstract: | The relationship between severe-grade cervical lesions and clusters of human papillomavirus (HPV) genotypes in a taxonomic classification was surveyed in 232 women with previous abnormal cytology. HPV co-infections were clustered according to phylogenetic criteria. Multiple infections were detected in 22.0% of the entire sample. Clade A10 (represented by HPV-6 and HPV-11) appeared more frequently in multiple infections than clade A9, which was represented by five of the most common high-risk types, including HPV-16. Although HPV-16 was the most frequent genotype, it was not more prevalent in multiple infections. Abortion and two or more sexual partners were risk-factors associated with HPV co-infections. Severe cervical dysplasia was associated with co-infections with oncogenic types from different clades, with the association being significant for the high-risk clades A7 and A9. |
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Keywords: | Cervical cancer cross-sectional study genotypes human papillomavirus multiple infections risk-factors |
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