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金仁方对非酒精性脂肪肝大鼠作用的实验研究
引用本文:刘庆生,陈芝芸,严茂祥,何蓓晖,项柏康.金仁方对非酒精性脂肪肝大鼠作用的实验研究[J].中华中医药学刊,2006,24(7):1242-1244.
作者姓名:刘庆生  陈芝芸  严茂祥  何蓓晖  项柏康
作者单位:1. 杭州市中医院消化内科,浙江,杭州,310007
2. 浙江中医药大学附属医院消化研究室,浙江,杭州,310053
摘    要:目的:观察金仁方对高脂饮食诱导的非酒精性脂肪肝大鼠肝功能及肝组织病理组织学的影响。方法:雄性W istar大鼠70只,随机分为正常组10只和造模组60只,分别以标准大鼠饲料和高脂饲料喂养12周。造模结束后,将造模组随机分为模型组,中药大、中、小剂量组和易善复组,分别以不同剂量的金仁方和易善复灌胃治疗,模型组和正常组予等容量的生理盐水灌胃,均连续8周。取肝组织HE染色观察大鼠肝脏脂肪变程度,酶法检测肝功能。结果:模型组大鼠肝组织脂肪变程度较正常组明显升高(P<0.01);应用中药大、中、小剂量治疗后肝组织脂肪变程度较模型组明显下降(P<0.01)。模型组大鼠肝肝功能明显高于正常组(P<0.01);应用中药大、中、小剂量治疗后大鼠肝组织中肝功能表达较模型组明显降低(P<0.05)。结论:金仁方能明显改善高脂饮食诱导的大鼠肝组织脂肪变性,及肝脏的病理学组织变化,这可能是其治疗高脂饮食诱导的非酒精性脂肪肝的作用机制之一。

关 键 词:脂肪肝  中医药疗法  金仁方
文章编号:1009-5276(2006)07-1242-03
修稿时间:2006年1月20日

The Effect of Chinese Herbs with Jin Ren Fang on Liver Tissues of Rats with Nonalcoholic Fatty Liver
Liu Qingsheng,Chen Zhiyun,Yan Maoxiang,He Beihui,Xiang Baikang.The Effect of Chinese Herbs with Jin Ren Fang on Liver Tissues of Rats with Nonalcoholic Fatty Liver[J].Chinese Archives of Traditional Chinese Medicine,2006,24(7):1242-1244.
Authors:Liu Qingsheng  Chen Zhiyun  Yan Maoxiang  He Beihui  Xiang Baikang
Abstract:Objective: To investigate the Liver function and liver tissues pathology and assess the effects of Jin Ren Fang in rats with fatty liver induced high-fat diet.Methods:70 Wistar rats were randomly divided into the normal group and the model group.The 60 rats in the model group were given by high-fat diet everyday.The 10 rats in the normal group were given the standard diet.After the model being built,the rats in the model group were divided into the fatty-liver model,the big,the middle,the small dosage Herb groups and the A.Nattermam groups,and were disposaled with differented dosage of Chinese herbs with Jin Ren Fang and A.Nattermam.The rats in the normal and fatty-liver model group were given the same capacity saline with daily gavage,after 8 weeks.The severity of fatty-liver were measured by semiquantitative scoring.The degree of liver function was detected by enzyme method.Results: Compared with the normal group,the severity of the fatty-liver scoring in rats of the fatty-liver model group were obviously higher(P<0.01).Compared with the fatty-liver model group,the severity of fatty-liver in rats of all Herb group were obviously lower(P<0.01). Compared with the normal group,the degree of liver function in the fatty-liver model group were significantly higher(P<0.01).Compared with the fatty-liver model group,the degree of liver function in all the Herb group were lower(P<0.05).Conclusion:Jin Ren Fang can relieve the degree of fatty-liver in rats with fatty liver induced high fat diet and the liver tissue pathology.
Keywords:fatty liver  TCM therapy  Jin Ren Fang
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