| 异构体(R,R)-XY和(S,S)-XY对兔眼血流的影响(英文) |
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| 引用本文： | 彭洁,邹艳红,江伟,计晓斌,陈欣宇,张奕华,彭司勋,邱春亿.异构体(R,R)-XY和(S,S)-XY对兔眼血流的影响(英文)[J].国际眼科杂志,2008,8(3):437-441. |
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| 作者姓名： | 彭洁 邹艳红 江伟 计晓斌 陈欣宇 张奕华 彭司勋 邱春亿 |
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| 作者单位： | 1. 美国得克萨斯农工大学医学院眼科药理研究所
2. 中国药科大学新药物研究中心,中国江苏省南京市,210009 |
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| 基金项目： | 中国国家自然科学基金资助项目(No.30472085)，美国德州农工大学医学院眼科药理研究所资助~~ |
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| 摘 要： | 目的:研究两组异构体(R,R)-XY-1到(R,R)-XY-12以及(S,S)-XY-1到(S,S)-XY-12对兔眼血流的影响。方法:用彩色微球技术测量兔眼在高眼压下(40mmHg)各组织的血流情况。结果:12个(R,R)-XY化合物以10g/L,50μL的剂量滴入兔眼,其中4个化合物可提高脉络膜血流。所有(S,S)-XY系列的化合物对兔眼血流没有影响。结论:(R,R)-XY系列中一些化合物可以增加兔眼血流,这些可能对眼部血流降低相关疾病的防治有作用。在24个化合物中,(R,R)-XY-1和(R,R)-XY-9最有药效。
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| 关 键 词： | 眼血流 缺血 异构体 |
Effects of enantiomers(R,R)-XY and(S,S)-XY on ocular blood flow in rabbits |
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| Jie Peng,Yan-Hong Zou,Wei Jiang,Xiao-Bin Ji,Xin-Yu Chen,Yi-Hua Zhang,Si-Xun Peng,George C Y Chiou.Effects of enantiomers(R,R)-XY and(S,S)-XY on ocular blood flow in rabbits[J].International Journal of Ophthalmology,2008,8(3):437-441. |
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| Authors: | Jie Peng Yan-Hong Zou Wei Jiang Xiao-Bin Ji Xin-Yu Chen Yi-Hua Zhang Si-Xun Peng George C Y Chiou |
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| Institution: | Jie Peng1, Yan-Hong Zou1, Wei Jiang1, Xiao-Bin Ji2, Xin-Yu Chen2, Yi-Hua Zhang2, Si-Xun Peng2, George C Y Chiou1 1Institute of Ocular Pharmacology and Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University System Health Science Center, College Station, TX 77843, USA 2Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, Jiangsu Province, China |
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| Abstract: | ·AIM: To evaluate the effects of two series of enantiomers (R, R)-XY-1 through (R, R)-XY-12 and (S,S)-XY-1 through (S, S)-XY-12] on ocular blood flow in rabbits.·METHODS; Colored microsphere technique was used for in vivo experiments to determine the ocular blood flow in various tissues of ocular hypertensive (40mmHg) rabbit eyes.·RESULTS; Of the twelve compounds of ( R, R)-XY series examined, four increased choroidal blood flow at 10g/L, 50uL instilled into eyes. All compounds of (S, S)-XY series were not effective on ocular blood flow.·CONCLUSION; Some compounds of (R, R)-XY series increased the ocular blood flow, which might be useful for the prevention and treatment of ocular blood flow related eye diseases. Among all twenty-four compounds, (R, R)-XY-1and (R, R)-XY-9 seem to be the most potent ones.KEYWORDS; ocular blood flow; ischemia; enantiomer |
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| Keywords: | ocular blood flow ischemia enantiomer |
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