自发性高血压大鼠血中内皮素、一氧化氮、丙二醛水平及其意义

为探讨内皮素(ET)、一氧化氮(NO)在高血压发病中的作用及相互关系。选用自发性高血压大鼠(SHR)和对照WKY大鼠各10只,分别测定血浆中NO(?)/NO (?),MDA及ET水平,分析血压与ET、NO及MDA与NO的关系。结果SHR血浆中的NO(?)/N0(?)、ET、MDA水平明显高于对照组(P<0.01),同时SHR血压与ET水平独立相关,偏相关系数为0.8855(P<0.01),MDA与NO(?)/NO(?)正相关(r=0.8714,P<0.01)。结果提示,ET水平升高在高血压发病中起重要作用,血浆NO升高是一种代偿反应,但NO过度升高参与高血压的发展,并可能与高血压的并发症有关。

The Plasma Levels of Endothelin Nitric Oxide and MDA and Their Significance in SHR

To investigate the role of nitric oxide (NO) and endothelin(ET) in the occurrence of hypertension,and the relationship between each other. 10 spontaneous hypertensive rats (SHR) and 10 wistarkyoto rats (WKY)were used in determining the levels of Nitrite/nitrate (NO2-/NO3-) ,MDA and ET in plasma. The plasma levels of (NO2-/NO3-),MDA,ET in SHR was significantly higher than that in WKY( P <0. 01). There was a positive correlation between blood pressure and plasma ET level,coefficient of partial correlation was 0. 8853( P <0. 01) .There was a positive correlation between MDA and NO2-/NO3- in plasma( r=0. 8714, P <0. 01). Increased ET play an important role in the occurrence of hypertension. Higher plasma NO levels in SHR may be due to compensatory mechanism respending to higher ET level resulting in hypertension,but excesive NO may be reference to complication of hypertension. Compesatory mechanism respending to higher ET eve! resulting in hypertension, but excesive NO may be referene to compication of hypertension.