早期药物联合心理干预治疗急性脑梗死后抑郁患者的疗效观察

目的探讨早期药物联合心理干预对急性脑梗死后抑郁症状和神经功能恢复的影响。方法选取90例急性脑梗死后抑郁患者,汉密尔顿抑郁量表(HAMD-17)评分均≥8分,随机分为治疗组和对照组,治疗组配合药物(氟西汀)并联合心理干预治疗,对照组单纯药物(氟西汀)治疗。在治疗前、治疗后2、4和8周分别对患者行HAMD-17和神经功能缺损程度(SSS)评分。结果治疗后2、4和8周治疗组患者HAMD-17和SSS评分明显优于对照组(P均<0.01)。抑郁症状和神经功能临床疗效治疗组明显优于对照组(P<0.01或P<0.05)。结论早期药物联合心理干预治疗对脑梗死后抑郁患者具有很好的疗效。

Therapeutic effect of combined mental intervention and early stage medicine treatment on post-stroke depression

Objective To explore the curable effect of early mental intervention and fluoxetin on patients with post-stroke depression.Method 90 patients of post-stroke depression were randomly divided into the control treatment group and the comprehensive therapy group(therapy of mental intervention and fluoxetin) before treatment.All patients were given fluoxetin orally 20 mg once a day.The comprehensive therapy group was given mental intervention additionally.The clinical therapeutic effect,the HAMD-17 and SSS were observed before treatment and at the ends of 2nd,4th and 8th week after treatment.Results The clinical therapeutic effect,the HAMD-17 and SSS of the comprehensive therapy group were improved significantly(P<0.01 or P<0.05).Conclusion The early comprehensive therapy of mental intervention and fluoxetin was an effective preparation for treatment of post-stroke depression patients.