神经节苷脂治疗中重度新生儿缺氧缺血性脑病的近期疗效分析

目的:探讨单唾液酸四己糖神经节苷脂钠(GMI)对新生儿缺氧缺血性脑病(HIE)的疗效.方法:将172例中、重度HIE患儿随机分为治疗组88例和对照组84例,两组均给予常规治疗,治疗组加用GMI 20 mg/d静脉滴注,疗程10 d.两组患儿由专人对临床症状及体征消失时间进行登记和疗效评估.结果:治疗组与对照组总有效率分别为92.0％和70.2％(x2=13.49,P＜0.05)；两组胃肠功能紊乱消失时间(P＜0.05)、循环不良消失时间(P＜0.01)、意识恢复时间(P＜0.01)、神经反射恢复时间(P＜0.01)、肌张力恢复时间(P＜0.01)比较差异均有统计学意义.结论:在常规治疗基础上加用GMI治疗HIE能有效控制缺氧缺血所致的脑水肿,显著改善患儿临床症状.

Short-Term Effects of Monosialotetrahexosylganglioside Sodium Injection for Moderate to Severe Neonatal Hypoxic-Ischemic Encephalopathy

Objective:To observe the treatment effects of Monosialotetrahexosylganglioside Sodium Injection(GMI) on the neonatal hypoxic-ischemic encephalopathy(HIE).Methods:One hundred and seventy two neonates with moderate to severe HIE were randomly divided into a study group,containing 88 cases,with GMI(Daily/time 20 mg,Course of treatment:10 day) and standardization treatment;a control group,containing 84 cases,with standardization treatment.In both groups the clinical symptoms and disappearance time of signs were observed and compared.Curative effects were evaluated.Results:The treatment effects of the study group was 92.0%,while that of the control group was 70.2%(χ2=13.49,P<0.05).The differences between both groups’ gastrointestinal disorder disappearance time(P<0.05),poor circulation disappearance time(P<0.01),recovery of consciousness(P<0.01),reflex recovery time(P<0.01),muscle tone recovery time(P<0.01) were statistically significant.Conclusions:The GMI treatment based on the standardization treatment can control the hypoxic-ischemic brain edema effectively,and ameliorate the clinical symptoms of newborn.obviously.