p53在结肠癌中的表达及临床意义

目的 :研究 p5 3在结肠癌中的表达 ,探讨 p5 3在结肠癌中的表达与结肠癌发生、发展及预后的关系。 方法 :选用结肠癌组织标本 33例及相应的癌旁正常组织标本 33例 ,通过免疫组织化学检测 p5 3在结肠癌组织及癌旁正常组织中的表达 ,分析 p5 3在结肠癌中的表达与结肠癌临床病理参数之间的关系。 结果 :p5 3在结肠癌组的阳性表达率为 6 0 6 % ,在癌旁正常组织组的阳性表达率为 15 1%。两者之间存在显著差异 (P <0 0 1) ;对p5 3在结肠癌中的阳性表达与结肠癌的Dukes分期及癌细胞的分化程度作相关性分析 ,结果显示 ,p5 3的阳性表达与Dukes分期有关 (P <0 0 5 ) ,p5 3的阳性表达与癌细胞分化程度有关 (P <0 0 5 ) ;结论 :研究证明了结肠癌组织中 p5 3存在异常高表达 ,较癌旁正常组织明显增高 ,结肠癌组织中 p5 3的阳性表达与结肠癌Dukes分期及癌细胞分化程度有明显相关性。说明p5 3的突变在结肠癌的形成和发展中起了促进作用 ,同时说明 p5 3有可能作为结肠癌发生、发展及预后的肿瘤标志物。

Expression and Clinical Significance of p53 in Colon Cancer

Objective: To study the expression of p53 in tumor tissues and to investigate its value in development and prognosis of colon cancer. Methods: The expression of p53 in 33 colon cancers and normal para-cancer colon tissues were examined by immunohistochemical technique. The relation between the expression of p53 in colon cancer and the parameters of clinic pathology of colon cancer were analyzed. Results:The positive rate of p53 in the colon cancer group was 60.6% and that in the normal para-cancer group was 15.1%. The difference between the two groups was significant (P<0.01). Relevance was analyzed between positive expression of p53 in the colon cancer and Dukes stages or differentiated grades of the colon cancer. The positive expression of the p53 was observed significant correlation with Dukes stages and differentiated grades of the colon cancer (P<0.05). Conclusion: There was overexpression of p53 in the colon cancer tissues. The expression of p53 in the colon cancer tissues was significantly higher than that in the normal para-cancer tissues. The positive expression of the p53 was observed significant correlation with Dukes stages and differentiated grades of the colon cancer. The results suggested the mutation of p53 promoted the tumorigenesis and development of colon cancers, and p53 would be used as a new tumor marker in tumorigenesis,as well as development and prognosis of colon cancer.