| 氧化苦参碱对环磷酰胺抗癌活性和毒性的影响 |
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| 引用本文： | 袁寀,吕式琪,姚娴.氧化苦参碱对环磷酰胺抗癌活性和毒性的影响[J].药学学报,1987,22(4):245-249. |
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| 作者姓名： | 袁寀 吕式琪 姚娴 |
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| 作者单位： | 首都医学院药理教研室 北京
(袁寀，吕式琪)，首都医学院药理教研室 北京(姚娴) |
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| 摘 要： | 氧化苦参碱能够诱导小鼠肝细胞微粒体细胞色素P-450。氧化苦参碱与环磷酰胺合用对艾氏癌实体型有协同抑制作用,机制之一为氧化苦参碱提高了环磷酰胺的代谢激活,并使环磷酰胺减少剂量1/2,其抑瘤作用仍相当于原剂量,而环磷酰胺引起白细胞降低的毒性明显减轻。
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| 关 键 词： | 氧化苦参碱 细胞色素P-450 环磷酰胺 |
| 收稿时间： | 1986-08-01 |
EFFECTS OF OXYMATRINE ON THE ANTITUMOR ACTIVITY AND TOXICITY OF CYCLOPHOSPHAMIDE IN MICE |
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| YUAN Cai,LU Shi-Qi and YAO Xian.EFFECTS OF OXYMATRINE ON THE ANTITUMOR ACTIVITY AND TOXICITY OF CYCLOPHOSPHAMIDE IN MICE[J].Acta Pharmaceutica Sinica,1987,22(4):245-249. |
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| Authors: | YUAN Cai LU Shi-Qi and YAO Xian |
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| Abstract: | Oxymatrine (OMT) was isolated from Sophora flavescens Alt. Studies showed that the content of hepatic microsomal cytochrome P-450 (P-450) was significantly increased by OMT (100mg/kg). Increased antitumor effect and content of P-450 were found in Ehrlich carcinoma-bearing mice with OMT (100mg/kg) plus cyclophosphamide (CPA) (60 mg/kg). The synergism of antitumor effect was due to increased level of alkylating metabolites of CPA by OMT. Furthermore, antitumor effect of OMT (100mg/kg) plus CPA (30mg/kg) was similar to that of CPA (60mg/kg) but inhibitory effect of CPA on WBC was reduced. |
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| Keywords: | Oxymatrine Cytochrome P-450 Cyclophosphamide |
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