传染性非典型肺炎患者凝血功能的变化

目的 观察传染性非典型肺炎(严重急性呼吸综合征,SARS)患者在发病急性期和治愈后不同时期的凝血功能改变。方法 检测在急性期和治愈后不同时期SARS患者血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血浆纤维蛋白原含量(FIB)和血浆D-二聚体含量(DD)的变化。结果 与SARS恢复期相比,患者发病急性期的PT、APTT明显延长(P<0.01),FIB极显著升高(P<0.0001),DD含量显著升高(P<0.01)。急性期SARS患者血浆PT、APTT、FIB和DD异常的阳性率分别为31.8％、53.2％、80.9％和50％。结论 在SARS发病急性期,大部分患者存在高纤维蛋白原血症,约1/2的患者有凝血功能障碍和轻度继发性纤溶亢进,重症患者可并发DIC。SARS患者治愈后,凝血功能可逐渐恢复正常。

The blood coagulation abnormity of severe acute respiratory syndrome patients

Objective To investigate the blood coagulation function of the severe acute respiratory syndrome (SARS)patients during acute phase and recovery stage. Methods The plasma prothrombin time (PT) , activated partial thromboplastin time (APTT) , fibrinogen (FIB) and D-Dimer of SARS patients in different stage were detected. Results By contrast with SARS recovery stage, PT, APTT, FIB and D-Dimer in the acute phase of SARS patients increased markedly ( P < 0. 01 ) . The positive percent of an increased PT, APTT, FIB and D-Dimer during acute phase of SARS were 31. 8% ,53. 2% ,80. 9% and 50% respectively. Conclusion During the acute phase of SARS, hyperfibrinogenemia was present in a majority of the SARS patients, a hypocoagulation and hyperfibrinolysis was in about half of the patients. Disseminated intravascular coagulation (DIC) may be an intercurrent disorder in the severe patients. The blood coagulation function can be back to normal gradually after SARS patients cured.