EAU guidelines on testicular cancer: 2011 update |
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Authors: | Albers Peter Albrecht Walter Algaba Ferran Bokemeyer Carsten Cohn-Cedermark Gabriella Fizazi Karim Horwich Alan Laguna Maria Pilar;European Association of Urology |
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Institution: | a Department of Urology, Düsseldorf University, Düsseldorf, Germany b Department of Urology, Rudolfstiftung, Vienna, Austria c Department of Pathology, Fundacio Puigvert, Barcelona, Spain d Department of Medical Oncology, Universitätskliniken Eppendorf, Hamburg, Germany e Department of Oncology, Karolinska University Hospital, Stockholm, Sweden f Department of Medicine, University of Paris XI, Villejuif, France g Academic Unit of Radiotherapy and Oncology, Royal Marsden NHS Trust & The Institute of Cancer Research, Sutton, UK h Department of Urology, Amsterdam Medical Center, Amsterdam University, Amsterdam, The Netherlands |
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Abstract: | ContextOn behalf of the European Association of Urology (EAU), guidelines for the diagnosis, therapy, and follow-up of testicular cancer were established.ObjectiveThis article is a short version of the EAU testicular cancer guidelines and summarises the main conclusions from the guidelines on the management of testicular cancer.Evidence acquisitionGuidelines were compiled by a multidisciplinary guidelines working group. A systematic review was carried out using Medline and Embase, also taking Cochrane evidence and data from the European Germ Cell Cancer Consensus Group into consideration. A panel of experts weighted the references, and a level of evidence and grade of recommendation were assigned.ResultsThere is a paucity of literature especially regarding longer term follow-up, and results from a number of ongoing trials are awaited. The choice of treatment centre is of the utmost importance, and treatment in reference centres within clinical trials, especially for poor-prognosis nonseminomatous germ cell tumours, provides better outcomes. For patients with clinical stage I seminoma, based on recently published data on long-term toxicity, adjuvant radiotherapy is no longer recommended as first-line adjuvant treatment. The TNM classification 2009 is recommended.ConclusionsThese guidelines contain information for the standardised management of patients with testicular cancer based on the latest scientific insights. Cure rates are generally excellent, but because testicular cancer mainly affects men in their third or fourth decade of life, treatment effects on fertility require careful counselling of patients, and treatment must be tailored taking individual circumstances and patient preferences into account. |
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Keywords: | EAU Guidelines Testicular cancer Assessment Diagnosis Treatment Follow-up |
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