烟酰胺对肺源性心脏病患者肺动脉压及血浆内皮素的影响

目的探讨钾通道开放剂烟酰胺对肺源性心脏病患者肺动脉压和血浆内皮素-1(ET-1)的影响。方法78例肺源性心脏病肺动脉高压患者,随机分为烟酰胺治疗组(观察组)40例和对照组38例,分别测定2组患者治疗前、后肺动脉平均压和ET-1的变化。结果治疗前观察组和对照组肺动脉压、ET-1无明显差异(P>0.05);治疗后观察组肺动脉压、ET-1均较治疗前明显降低(P<0.001);对照组肺动脉压、ET-1治疗后与治疗前相比无统计学意义(P>0.05);观察组治疗后肺动脉平均压、ET-1较对照组显著降低(P<0.001)。结论烟酰胺可减少ET-1的分泌和释放,保护内皮细胞,从而降低肺动脉高压,减轻右心负荷,改善临床症状。

Effect of nicotilamide on pulmonary artery pressure and plasmic endothelin in patients with cor pulmonale

Objective To explore the effect of nicotilamide on pulmonary arterial pressure and plasma endotheline(ET-1) in patients with chronic cor pulmonale.Methods Seventy-eight cases with cor pulmonale and pulmonary hypertension were randomly divided into two groups,nicotilamide treatment group(A group) and control group(B group).The mean pulmonary artery pressure and plasma endotheline-1 concentration were detected pre-and post-treatment respectively.Results The mean pulmonary artery pressure and plasma endotheline-1 concentration were no statistical differences between A group and B group pre-treatment(P>0.05).The mean pulmonary artery pressure and plasma endotheline-1 concentration post-treatment were lower than pre-treatment in A group(P<0.001).But there was no statistical differences in B group(P>0.05).And The mean pulmonary artery pressure and plasma endotheline-1 concentration in A group were significantly lower than that in B group post-treatment(P<0.001).Conclusion Nictinamide can reduce the secretion and release of plasma endotheline-1,protect endothelial cells,thereby it can decrease pulmonary hypertension,lightened right-sided heart load and improve the clinical symptoms.