原发性肝癌介入治疗前后血清VEGF,SIL-2R水平变化及意义

目的：检测血清VEGF,SIL-2R在原发性肝癌介入治疗（TACE）前后水平变化。方法：30例临床确诊的原发性肝癌患者分别于介入术前1天、术后1天、7天、1月清晨空腹留取静脉血3ml,分离血清-70℃保存。VEGF,SIL-2R的测定采用ELISA法。结果：30例原发性肝癌患者血清VEGF水平在术前1天、术后1天、7天、1月的均值与术前比较,术后1天明显升高,差异有统计学意义（P〈0.05）;术后7天值明显下降,与术前及术后1天比较均有统计学意义（P〈0.05）;术后1月与术后7天比较升高,差异有统计学意义（P〈0.05）,与术前比较差异无统计学意义（P〉0.05）;血清SIL-2R水平术后1天与术前比较差异无统计学意义（P〉0.05）,术后7天与术前及术后1天比较均下降,且差异有统计学意义（P〈0.05）,术后1月与术后7天比较均上升差异有统计学意义（P〈0.05）,但明显低于术前,差异有统计学意义（P〈0.05）。结论：（1）血清VEGF,SIL-2R水平在原发性肝癌介入治疗前后存在明显的动态变化。（2）血清VEGF,SIL-2R检测有望成为原发性肝癌介入治疗疗效评价指标。

Clinical significance of measument of changes in serum VEGF and SIL-2R contents before and aftertranscatheter arterial chemo-embolization in patients with hepatocellular carcinoma

Objective：To investigate the levels of VEGF,and SIL-2R（serum soluble interleukin-2 receptor）in serum in the primary liver cancer before and after transcatheter arterial-embolization（TACE）.Methods：Fasting venous blood（3ml）were collected from 30 cases with clinical diagnosis of hepatocellular carcinoma in the morning,respectively on the 1st day before operation,the 1st,7th day and 1 month after interventional therapy.At low temperature,serum was separated and stored in -70℃,VEGF,SIL-2R was detected with ELISA.Results：Serum VEGF levels at the 1st day before the TACE,at the 1st day,7th day,and 1 month after the treatment was significantly increased at 1st after operation when compared with 1st before operation,There was statistically significant difference（P〈0.05）,it significantly decreased at 7th day compared with 1st before operation,and 1st after operation.,there was statistically significant difference （P〈0.05）,it significantly increased at 1 month compared with 7th day after operation,there was statistically significant difference （P〈0.05）,but there was no significant difference compared with 1st before operation（P〈0.05）.Serum SIL-2R levels at the 1st day before the TACE,at the 1st day,7th day,and 1 month after treatment compared with 1st before operation serum SIL-2R levels at 1st after operation was no significant difference（P〈0.05）,but serum SIL-2R levels significantly decreased at 7th compared with 1st before operation,and1st after operation.There was statistically significant difference（P〈0.05）,increased at 1 month compared with 7th day after operation （P〈0.05）,but significantly lower than 1st before operation（P〈0.05）.Conclusions：（1）serum VEGF,SIL-2R levels have a significant dynamic change following TACE treatment.（2）Dection of serum VEGF,SIL-2R could be used as effictive evaluation indicators of transcatheter arterial-embolization