| The Construction and Investigation of PLGA Artificial Bone by Biomimetic Mineralization |
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| 作者姓名： | 赵铭 郑启新 王金光 王运涛 郝杰 |
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| 作者单位： | Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China，Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China，Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China，Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China，Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China |
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| 摘 要： | Tissueengineeringstrategieshavebeenpro posedtotreatbonetissueloss.Comparedwithotherbiomaterials,PLGAissatisfactorytoclinicalusebecauseofitsabsorbabilityandsufficientbio compatibility.However,thehighlyhydrophobicsurfaceofPLGAlimitscellsurfaceadhesion1].Itisimportanttoimprovecellularattachment,sprea dingandgrowthfortheclinicaluseofPLGA.Oneapproachtomakebiomaterialsactivelyinteractwithsurroundingtissuesistoprovidebiologicalcoatingtomimicextracellularmatrix.Apatitecoatingonthesurfaceofbioma…
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| 关 键 词： | 人工骨 矿化作用 仿生学 治疗 |
| 收稿时间： | 2005-06-26 |
The construction and investigation of PLGA artificial bone by biomimetic mineralization |
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| Zhao Ming,Zheng Qixin,Wang Jinguang,Wang Yuntao,Hao Jie.The Construction and Investigation of PLGA Artificial Bone by Biomimetic Mineralization[J].Journal of Zuazhong University of Science and Technology: Medical Edition,2005,25(6):687-689. |
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| Authors: | Zhao Ming Zheng Qixin Wang Jinguang Wang Yuntao Hao Jie |
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| Institution: | Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022, China |
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| Abstract: | Summary To modify the surface property of poly lactide-co-glycolide (PLGA) by biomimetic mineralization to construct a new kind of
artificial bone. PLGA films and 3-diamensional (3-D) porous scaffolds hydrolyzed in alkaline solution were mineralized in
SBF for 14 days. The morphology and composition of the mineral grown on PLGA were analyzed with SEM, FTIR and XRD. The porosity
of the scaffolds was detected by using the liquid displacement method. The compressive strength of the scaffolds was detected
by using a Shimadzu universal mechanic tester. An obvious mineral coating was detected on the surface of films and scaffolds.
The main component of the mineral was carbonated hydroxyapatite (HA) similar to the major mineral component of bone tissues.
The porosity of the un-mineralized and mineralized porous scaffolds was (84.86±8.52) % and (79.70±7.70) % respectively. The
compressive strength was 0.784±0.156 N/mm2 in un-mineralized 3-D porous PLGA and 0.858±0.145 N/mm2 in mineralized 3-D porous PLGA. There were no significant differences between the mineralized and un-mineralized scaffolds
(P>0.05) in porosity and biomechanics. Biomimetic mineralization is a suitable method to construct artificial bone.
ZHAO Ming, male, born in 1974, Doctor in Charge |
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| Keywords: | Poly lactide-co-glycolide Mineralization artificial bone Biomechanics |
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