蒙药玉簪花中的甾体化合物

 目的 研究玉簪［Hosta plantaginea （Lam.）Aschers］花的化学成分。方法 利用溶剂法进行提取和萃取分部，采用硅胶柱色谱、Sephadex LH-20柱色谱进行分离，利用理化鉴别及现代波谱分析技术鉴定化合物的结构。结果 从中分离鉴定了6个甾体化合物，分别为(25R)-5α-螺旋甾烷-2α，3β-二醇（支脱皂苷元）（1）， (25R)- 2α，3β-二醇-5α-螺旋甾烷-12-酮（曼诺皂苷元）（2），胡萝卜苷（3），支脱皂苷元-3-O-{O-β-D-吡喃葡萄糖基(1→2)-O-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃半乳糖苷}（4），支脱皂苷元-3-O-{O-β-D-吡喃葡萄糖基(1→2)-O-［β-D-吡喃木糖基(1→3)］-O-β-D-吡喃葡萄糖基-(1→4)-β-D-吡喃半乳糖苷}（5）和支脱皂苷元-3-O-{O-β-D-吡喃葡萄糖基-(1→2)-O-［O-α-L-呋喃鼠李糖基-(1→4)-β-D-吡喃木糖基(1→3)］-O-β-D-吡喃葡萄糖-(1→4)-β-D-吡喃半乳糖苷}（6）。结论 6个化合物均为首次从该植物中得到。

Steroidal Constituents from Flowers of a Mongolia Herb,Hosta plantaginea (Lam.) Ascherson

OBJECTIVE To investigate the chemical constituents of the flowers of Hosta plantaginea (Lam.) Aschers. METHODS The chemical constituents were isolated by silica gel and Sephadex LH-20 column chromatography and elucidated on the basis of physiochemical properties and spectral analysis. RESULTS Six steroidal compounds were isolated from the flower of H. plantaginea and identified as (25R)-5α-spirostan-2α，3β-diol (gitogenin) (1)， (25R)-2α，3β-diol-5α-spirostan-12-one (manogenin) (2)， daucosterol (3)， gitogenin-3-O-{-O-β-D-glucopyranosyl-(1→2)-O-β-D-glucopyranosyl-(l→4)-β-D-galactopyranoside} (4)， gitogenin-3-O-{O-β-D-glucopyranosyl-(1→2)-O-［β-D-xylopyranosyl-(1→3)］-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside} (5)， gitogenin-3-O-{O-β-D-glucopyranosyl-(1→2)-O-［O-α-L-rhamnopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)］-0-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside}(6). CONCLUSION All of the compounds were isolated from H. plantaginea for the first time.