新生儿高间接胆红素血症患儿凝血象的研究及临床意义

目的　探讨凝血因子、血小板和新生儿高间接胆红素血症的关系 ;方法　用散射比浊法测定新生儿高间接胆红素血症患儿 6 0例和正常足月新生儿 2 0例的凝血酶原时间 (PT)、激活的部分凝血活酶时间 (APTT) ,同时检查血小板计数和肝功能 ;结果　新生儿高间接胆红素血症患儿的PT、APTT比正常足月新生儿组明显升高 ,有显著性差异 ,P值均 <0 .0 5 ,而血小板计数和肝功能两组间比较 ,无显著性差异 ,P值 >0 .0 5 ;结论　新生儿高间接胆红素血症患儿临床上常出现脐部渗血、穿刺部位出血不止等表现与新生儿血小板数量无关 ,而与PT、APTT延长有关 ,可能由于母乳喂养的推广和生后没有进行常规维生素K预防。因此 ,我们建议在治疗新生儿高胆红素血症的同时 ,要注意预防维生素K的缺乏。

Stud on the coagulative factors of patients with indirect hyperbilirubinemia in neonatal

Objective: In order to investigate the relationships between the neonatal indirect hyperbilirubinemia and the coagulative factors?blood platelet, Nephelometric was taken to detect the PT?APTT of 60 patients with indirect hyperbilirubinemia and 20 normal full-term neonates. Meanwhile, the blood platelet counts and liver functions were also detected. The results showed PT and APTT of the patients with indirect hyperbilirubinemia were prolonged, compared with those of the normal neonates, with significant difference (P<0.05). however, the blood platelet count and liver functions of the patients were not prolonged. It suggests in clinic the bleeding predisposition presented in the neonatal hyperbilirubinemia may be associated with the prolonged PT and APTT.