肺表面活性物质联合机械通气与持续正压通气治疗新生儿肺透明膜病的疗效比较

目的 观察肺表面活性物质联合经鼻塞持续正压通气(NCPAP)与机械通气(MCV)对新生儿肺透明膜病(HMD)的治疗效果,并比较其呼吸机相关性肺炎等并发症的发生情况.方法 将2009年1月-2011年3月在厚街医院确诊为HMD的25例患儿随机分为MCV组(13例)和NCPAP组(12例);两组均应用肺表面活性物质(PS)...

Comparison study on curative effects of pulmonary surfactant combined with NCPAP and MCV on treatment of hyanline membrane disease

Objective To observe and compare the effect of pulmonary surfactant combined with nasol continous positive airway pressure(NCPAP) and machine ventilation(MCV) on treatment of severe hyaline membrane disease (HMD) in neonates. Methods 25 preterm newborns with Ⅲ～Ⅳ degree HMD were randomly allocated into NCPAP and MCV groups: 12 cases with hyeline membrane disease to NCPAP who were given pulmonary surfactant machine ventilation combined with pulmonary surfactant served as control group. Blood gas analysis, FiO2, duration of ventilation and length of stay in NICU, complications, hospitalization were compared between two groups. Results Blood gases improved at the time of 6 hours after treatment in the two groups(P ＜ 0.05). There were no significant difference between them(P ＞ 0.05). There were no significant difference between duration of ventilation, duration of oxygen therapy ,duration of hospitalization, rescue success rate and cure rate in the two groups (P＞ 0.05).The babies in NCPAP group had less incidence rate of pulmonary infection (P＜ 0.05) .Conclusion Preterm infants with hyaline membrane disease can achieve the improved prognosis by being managed with NCPAP combined with pulmonary surfactant, which has the advantages of less pulmonary infection than MCV.