| 持续性心房颤动患者心房肌中丝/苏氨酸蛋白磷酸酶活性变化及其意义 |
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| 引用本文： | 张超群,王志荣,程明月,徐晤,杨煜,吴建东. 持续性心房颤动患者心房肌中丝/苏氨酸蛋白磷酸酶活性变化及其意义[J]. 中国心脏起搏与心电生理杂志, 2011, 25(3): 213-215. DOI: CNKI:42-1421/R.20110610.0847.007 |
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| 作者姓名： | 张超群 王志荣 程明月 徐晤 杨煜 吴建东 |
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| 作者单位： | 徐州医学院附属医院心内科,江苏徐州,221000 |
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| 摘 要： | 目的检测持续性心房颤动(简称房颤)患者心房肌中丝/苏氨酸蛋白磷酸酶的活性变化并探讨其意义。方法用荧光法检测16例持续性房颤及14例窦性心律患者右心耳心肌组织中三种丝/苏氨酸蛋白磷酸酶的活性,同时采用Western blot技术检测第16位点丝氨酸磷酸化的受磷蛋白表达情况。结果与窦性心律组相比,持续性房颤组1型、2A型和2B型丝/苏氨酸蛋白磷酸酶活性均明显增加(P<0.01),第16位点丝氨酸磷酸化的受磷蛋白表达水平明显降低(P<0.01),且与1型和2A型丝/苏氨酸蛋白磷酸酶活性成负相关。结论持续性房颤患者心房肌丝/苏氨酸蛋白磷酸酶活性明显增加,其可能通过影响受磷蛋白磷酸化水平在心房电重构过程中发挥作用。
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| 关 键 词： | 心血管病学 心房颤动 受磷蛋白 丝/苏氨酸蛋白磷酸酶 |
The changes of the serine/threonine protein phosphatase activities in atrial tissue in patients with persistent atrial fibrillation |
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| ZHANG Chao-qun,WANG Zhi-rong,CHENG Ming-yue,XU Wu,YANG Yu,WU Jian-dong. The changes of the serine/threonine protein phosphatase activities in atrial tissue in patients with persistent atrial fibrillation[J]. Chinese Journal of Cardiac Pacing and Electrophysiology, 2011, 25(3): 213-215. DOI: CNKI:42-1421/R.20110610.0847.007 |
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| Authors: | ZHANG Chao-qun WANG Zhi-rong CHENG Ming-yue XU Wu YANG Yu WU Jian-dong |
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| Affiliation: | ZHANG Chao-qun,WANG Zhi-rong,CHENG Ming-yue,XU Wu,YANG Yu,WU Jian-dong.Department of Cardiology,Affiliated Hospital of Xuzhou Medical College,Xuzhou 221000,Jiangsu,China |
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| Abstract: | Objective To investigate the possible mechanism of electrical remodeling in persistent atrial fibrillation(PAF) by evaluating the changes of the Serine/Threonine protein phosphatase(Ser/Thr PP) activities in atrial tissue in patients with PAF.Methods The Ser/Thr PP activities in right atrial appendage tissue obtained from 16 patients with PAF and 14 patients with sinus rhythm(SR) were tested by use of ProFluor Ser/Thr PPase Assay while the phosphorylation level of 16-point serine residues of phospholamban(P... |
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| Keywords: | Cardiology Atrial fibrillation Phospholamban Serine/Threonine protein phosphatases |
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