| 拉米夫定联合干扰素治疗慢性乙型肝炎临床疗效Meta分析 |
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| 引用本文： | 孙翔,汪华. 拉米夫定联合干扰素治疗慢性乙型肝炎临床疗效Meta分析[J]. 江苏预防医学, 2011, 22(4): 38-41. DOI: 10.3969/j.issn.1006-9070.2011.04.013 |
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| 作者姓名： | 孙翔 汪华 |
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| 作者单位： | 1. 南京医科大学公共卫生学院,江苏,南京,210029;江苏省疾病预防控制中心,江苏,南京,210009
2. 江苏省疾病预防控制中心,江苏,南京,210009 |
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| 摘 要： | 目的:利用Meta分析方法,评价拉米夫定联合干扰素(LAM+IFN)与单独应用拉米夫定(LAM)治疗慢性乙型肝炎(CHB)患者的疗效差异。方法:检索相关文献,对符合纳入标准的10项随机对照研究,采用固定和随机效应模型进行Meta分析,共包括986例HBeAg阳性的慢性乙型肝炎患者。结果:拉米夫定联合干扰素组患者治疗12月,血清ALT复常率、血清HBV-DNA转阴率、血清HBeAg转阴率,均优于单用拉米夫定组,其差异有统计学意义[OR(95%CI)分别为1.74(1.28,2.34)、2.11(1.49,3.00)、3.66(1.87,7.20)]。结论:HBeAg阳性患者应用拉米夫定联合干扰素的治疗方案优于LAM单药疗法。
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| 关 键 词： | 慢性乙型肝炎 拉米夫定 干扰素 Meta分析 疗效比较 |
Interferon and lamivudine combination therapy versus lamivudine monotherapy for chronic hepatitis B treatment:a meta-analysisi of randomized controlled trials |
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| SUN Xiang,WANG Hua. Interferon and lamivudine combination therapy versus lamivudine monotherapy for chronic hepatitis B treatment:a meta-analysisi of randomized controlled trials[J]. Jiangsu Journal of Preventive Medicine, 2011, 22(4): 38-41. DOI: 10.3969/j.issn.1006-9070.2011.04.013 |
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| Authors: | SUN Xiang WANG Hua |
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| Affiliation: | SUN Xiang,WANG Hua(College of Public Health of Nanjing Medical University,Nanjing 210029,China) |
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| Abstract: | Objective:To compare lamivudine monotherapy versus lamivudine(LAM) combined with interferon(IFN) for treating chronic hepatitis B(CHB)patients with Meta-analysis.Methods:Related literatures were searched using computer,fixed and random effect models were applied to finish the Meta analysis for the 10 randomized control studies which conformed to the included criterion involving 986 patients were identified.Results:As the Meta-analysis showed,the therapeutic effect of lamivudine combined with interferon was ... |
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| Keywords: | chronic hepatitis B Lamivudine Interferon Meta-analysis therapy-effect comparison |
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