落新妇根镇痛、活血、止咳祛痰作用的研究

目的：研究落新妇根的镇痛、活血、止咳祛痰作用。 方法：采用小鼠热板法、小鼠扭体法观察其镇痛作用；用盐酸肾上腺素加冰水刺激复制血液流变学改变模型法观察其活血祛瘀作用；以小鼠氨水引咳法、小鼠酚红排泄法观察其止咳祛痰作用；以及通过观察小鼠最大耐受量来研究急性毒性等方面的药理作用。 结果：落新妇根能显著减少热板所致的小鼠舔足及醋酸引起的小鼠扭体反应次数；改善急性血瘀模型大鼠血液流变性；延长小鼠咳嗽潜伏期,减少咳嗽次数；增加小鼠气管内酚红分泌量；急性毒性实验小鼠灌胃最大耐受量为400 g·kg^﹣1相当成人日临床用量的666.7倍。结论：落新妇根具有镇痛、活血散瘀、止咳祛痰作用,临床应用安全。

Experimental studies of rhizoma Astilbes chinensis on its effects in abirritation, blood activation, cough relieving and sputum elimination

OBJECTIVE: To study the effects of rhizoma Astilbes chinensis in abirritation, blood activation, cough relieving and sputum elimination. METHOD: The antalgic function of rhizoma A. chinensis was tested by hot-plate method and writhing reaction. The acute blood-stasis model rats were made by Injection of adrenaline hydrochloride along with stimulation by ice water. The effects of cough relieving and sputum elimination were observed by the ammonia water-induced tussive mice and excretion of phenol red in the airway of mice. The maximum tolerance dose of rhizoma A. chinensis was also determined during the acute toxicity test. RESULT: The data were analyzed for statistical significance by t-test, which shows that the decoction of rhizoma A. chinensis is significantly effective in reducing the frequency of licking behavior of mice on hot-plate and writhing response induced by acetic acid, improving the hemarheology of acute blood-stasis model rats, prolonging the latent period, reducing the frequency of cough induced byammonia, and in increasing the quantity of phenol red output from the trachea in mice. The result acute toxicity test shows that maximum tolerance dose of gastrogavage in mice was 400 g x kg(-1). Which was 666. 7 times of that clinically used for human. CONCLUSION: Rhizoma A. chinensis has the effects of abirritation, blood activation, cough relieving and sputum elimination, and is safe in clinical application.