去氧孕烯炔雌醇片治疗青春期功能失调性子宫出血的疗效及安全性研究

目的:探讨去氧孕烯炔雌醇片治疗青春期功能失调性子宫出血的疗效及安全性。方法:选择青春期功能失调性子宫出血患者72例,随机分为实验组和对照组,分别采用去氧孕烯炔雌醇片治疗以及倍美力加甲羟孕酮治疗。观察并比较两组患者治疗前后控制出血时间和完全止血时间,并进行临床疗效的评价及不良反应观察。结果:实验组患者控制出血时间、完全止血时间均明显短于对照组(P<0.05)。实验组患者临床总有效率明显优于对照组(χ2=4.18,P<0.05)。实验组治疗期间出现不良反应5例,其中恶心3例,上腹部不适2例。对照组治疗期间出现不良反应14例,其中体重增加11例,恶心3例。实验组治疗期间出现不良反应的发生率明显低于对照组(χ2=5.79,P<0.05)。结论:去氧孕烯炔雌醇片治疗青春期功能失调性子宫出血安全有效,止血效果迅速,可作为治疗青春期功能失调性子宫出血的首选药物。

Efficacy and safety of marvelon on the treatment of adolescent dysfunctional uterine bleeding

Objectives： To explore the clinic efficacy and safety of Desogestrel and Ethinylestradiol Tablets （marvelon） on adolescent dysfunctional uterine bleeding （ADUB）. Method： Seventy -two ADUB patients were randomly divided into the ex- perimental group （treated by marvelon） and the control group （treated by Premarin combined with medrysone）. The control bleeding time and completely hemostatic time pre - and post - therapy of both the two groups were observed, and so were clinic efficacy and side effects. Results： The control bleeding time and completely hemostatic time of the experimental group were sig- nificantly shorter than those of the control group （ P 〈 0. 05 ）. The total effective rate of the experimental group was significantly higher than that of the control group（x2 = 4. 18 ,P 〈 0.05 ）. Five cases with side effects were found in the experimental group, three cases with nausea and two cases with discomfort in epigastrium. In the control group, fourteen cases with side effects were found, eleven cases with weight gain and three cases with nausea. The incidence rate of side effects of the experimental group was significantly lower than that of the control group （X2 = 5.79, P 〈 O. 05 ）. Conclusion： Marvelon is safe and effective in treating patients with ADUB. Featuring quick hemostasis, it can be the drug of first choice for patients with ADUB.