大剂量埃索美拉唑治疗急性非静脉曲张性上消化道出血疗效观察

目的观察大剂量埃索美拉唑在治疗急性非静脉曲张性上消化道出血的疗效及安全性。方法将74例急性非静脉曲张性上消化道出血患者随机分成2组,其中治疗组38例,给予首剂80 mg埃索美拉唑静脉注射,然后以8 mg/h的滴速持续滴注;对照组36例,给予埃索美拉唑40 mg静脉滴注,每12小时1次。72 h后评价2组病例的止血时间、再出血情况、输血量及不良反应。结果 2组不良反应发生率无明显差异,但治疗组止血率、止血时间、再出血发生率、平均输血量均优于对照组。结论大剂量埃索美拉唑治疗急性非静脉曲张性上消化道出血与常规剂量相比疗效明显,且起效迅速,安全可靠,再出血少,适用于大出血患者。

Clinical observation of treatment of acute nonvariceal upper gastrointestinal bleeding with high-dose of esomeprazole

Objective To observe the efficacy and safety of high dose of esomeprazole in the treatment of acute nonvariceal upper gastrointestinal bleeding.Methods 74 cases of acute nonvariceal upper gastrointestinal bleeding were randomly divided into 2 groups,38 cases in the treatment group,which was treated with the first agent of 80mg esomeprazole intravenous injection,and then with continuous infusion at the speed of 8mg/h.36 cases in the control group were treated with 40mg esomeprazole intravenous drip,once every 12 hours.The 2 groups were evaluated 72 hours after bleeding in terms of hemostatic time,re-bleeding,amount of blood transfusion and adverse reaction.Results The incidence of adverse reaction of the two groups had no significant difference,but the treatment group showed better result than the control group in hemostatic rate,bleeding time,re-bleeding rate,and average amount of blood transfusion.Conclusion Compared with conventional dose,high dose of esomeprazole has a better therapeutic effect in treating acute nonvariceal upper gastrointestinal bleeding.It is a rapid,safe and reliable therapy,suitable for patients with massive hemorrhage.