| 瘢痕中缺氧诱导因子-1α的表达及其与凋亡的关系 |
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| 引用本文： | 李高峰,谭军,钟茜,罗成群,刘浔阳.瘢痕中缺氧诱导因子-1α的表达及其与凋亡的关系[J].中华整形外科杂志,2006,22(2):113-115. |
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| 作者姓名： | 李高峰 谭军 钟茜 罗成群 刘浔阳 |
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| 作者单位： | 1. 410005,长沙,湖南省人民医院整形激光美容科
2. 中南大学湘雅三医院 |
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| 摘 要： | 目的 探讨瘢痕内缺氧环境减轻的机制。方法 采用免疫组化法检测烧伤后肉芽、不同时期瘢痕和正常皮肤中缺氧诱导因子-1α（hypoxia-inducible factor 1α，HIF-1α）、p53的表达，采用权重方法分别对各组瘢痕的HIF-1α、p53表达结果进行量化，分析各自规律及相互间关系。结果 随着瘢痕的成熟，HIF-1α表达强度逐渐减弱，p53表达强度在1年内逐渐增强，相互间具有负相关性（P〈0．01）。结论 p53在瘢痕成熟过程中起重要作用，HIF-1α可能通过协同p53诱导细胞凋亡，减少耗氧来减轻缺氧环境。
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| 关 键 词： | 缺氧诱导因子-1α p53 凋亡 缺氧 瘢痕 |
| 收稿时间： | 2004-11-16 |
| 修稿时间： | 2004年11月16 |
The expression of HIF-1α in scars and its relationship to apoptosis |
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| LI Gao-feng,TAN Jun,ZHONG Qian,LUO Cheng-qun,LIU Xun-yang.The expression of HIF-1α in scars and its relationship to apoptosis[J].Chinese Journal of Plastic Surgery,2006,22(2):113-115. |
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| Authors: | LI Gao-feng TAN Jun ZHONG Qian LUO Cheng-qun LIU Xun-yang |
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| Institution: | Department of Plastic and Cosmetic Surgery, Hunan Province People's Hospital, Changsha, China. |
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| Abstract: | OBJECTIVE: To explore the mechanism of hypoxic environment lessening in the course of scar maturation. METHODS: The expression of hypoxia inducible factor 1alpha (HIF-1alpha) and p53 in granulation of burn wound, burn scars of different stages, and normal skin was detected with immunohistochemical staining. The expressions were quantified by the weight method. The relationship between HIF-1alpha and p53 was investigated. RESULTS: With the scar maturation, the expression of HIF-1alpha gradually decreased while the expression of p53 gradually increased within one year. There was a negative correlation between HIF-1alpha and p53 (P < 0.01). CONCLUSION: p53 plays an important role in scar maturation. Associated with p53, HIF-1alpha may induce apoptosis, which decreases oxygen consumption and lightens hypoxia in the scar maturation. |
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| Keywords: | p53 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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