| 血清游离PSA与总PSA及其比值对前列腺癌的鉴别诊断价值 |
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| 引用本文： | 卢金环,季广厚,陈新.血清游离PSA与总PSA及其比值对前列腺癌的鉴别诊断价值[J].中国医疗前沿,2008,3(6). |
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| 作者姓名： | 卢金环 季广厚 陈新 |
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| 作者单位： | 卢金环,Lu Jinhuan(泗水县星村医院,山东,泗水,273209);季广厚,陈新,Ji Guanghou,Chen Xin(泗水县人民医院检验科,山东,泗水,273200) |
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| 摘 要： | 目的探讨血清游离前列腺特异性抗原(fPSA)和总前列腺特异性抗原(tPSA)及其比值(f/tPSA)对良性前列腺增生(BPH)与前列腺癌(PCa)鉴别诊断的临床价值。方法应用电化学发光法检测fPSA与tPSA并计算两者比值f/tPSA;计算不同f/tPSA对应的敏感性和特异性。结果虽然各指标在PCa与BPH组间存在显著性差异,但在4～10 ng/ml的诊断灰区,tPSA的PCa组(7.93±1.38)与BPH组(7.12±1.59)间无显著性差异(P>0.05),fPSA的PCa组(1.12±0.39)与BPH组(1.36±0.48)间也无显著性差异(P>0.05),而f/tPSA的PCa组(0.11±0.04)和BPH组(0.27±0.07)间有非常显著性差异(P<0.001)。结论在诊断灰区,用f/tPSA比值鉴别诊断前列腺癌比tPSA更有价值,以f/tPSA<0.16为诊断鉴别点比较适当。
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| 关 键 词： | f/tPSA 诊断灰区 前列腺癌 |
The Differential and Diagnostic Value for Prostate Cancer of the Serum Free PSA and Total PSA and Their Ratio |
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| Lu Jinhuan,Ji Guanghou,Chen Xin.The Differential and Diagnostic Value for Prostate Cancer of the Serum Free PSA and Total PSA and Their Ratio[J].China Healthcare Innovation,2008,3(6). |
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| Authors: | Lu Jinhuan Ji Guanghou Chen Xin |
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| Institution: | 1Xingcun Hospital of Sishui County in Shandong Province; Xingcun 273209; 2Department of Medical Laboratory Science; Sishui People s Hospital of Sishui County; Sishui 273200); |
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| Abstract: | Objective Discussion on the clinical differential diagnostic value for benign prostatic hyperplasia(BPH) and prostate cancer(PCa) of the serum free PSA,total PSA and their ratio.Methods Detection of fPSA and tPSA by means of electrochemiluminescence and calculation of the ratio;Calculates of the correspondent sensitivity and specificity of different f/tPSA.Results Although various specifications have significant difference in Pca and BPH,there is no significant difference between Pca group(7.93±1.38) and BP... |
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| Keywords: | f/tPSA |
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