The IL23 axis plays a key role in the pathogenesis of IBD |
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| Authors: | McGovern Dermot Powrie Fiona |
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| Affiliation: | Imperial College, London, Hammersmith Hospital Campus Du Cane Road, London W12 0HS, UK. dermotmcgovern@doctors.net.uk |
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| Abstract: | Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD. |
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