| 去卵巢骨质疏松模型大鼠L4脊椎骨的应力松弛与蠕变 |
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| 引用本文： | 张翘,张忠君,李新颖.去卵巢骨质疏松模型大鼠L4脊椎骨的应力松弛与蠕变[J].中国组织工程研究与临床康复,2011,15(26):4829-4832. |
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| 作者姓名： | 张翘 张忠君 李新颖 |
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| 作者单位： | 1. 吉林大学中日联谊医院,吉林省长春市,130031
2. 解放军空军航空大学基础部,吉林省长春市,130022 |
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| 摘 要： | 背景:去卵巢大鼠脊椎骨会发生哪些应力松弛与蠕变及时间的变化规律?目的:观察去卵巢骨质疏松对雌性大鼠承重骨黏弹性特性的影响。方法:Wistar雌性大鼠44只随机等分为对去卵巢骨质疏松动物模型组和对照组。模型组大鼠于0周摘除卵巢,14周后对大鼠L4椎骨进行应变增加速度为1%/s的应力松弛实验和应力增加速度为0.01MPa/s的蠕变实验,在7200s采集100个数据。结果与结论:大鼠L4椎骨对照组7200s应力松弛量和蠕变量大于模型组(P<0.05);同时大鼠L4椎骨应力松弛曲线是以对数关系变化的,蠕变曲线是以指数关系变化的。提示去卵巢骨质疏松大鼠椎骨黏弹性力学特性发生了改变。
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| 关 键 词： | 去卵巢 骨质疏松 L4椎骨 流变特性 大鼠 |
L_4 vertebra stress relaxation and creep properties in ovariectomized rats with osteoporosis |
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| Zhang Qiao,Zhang Zhong-jun,Li Xin-ying.L_4 vertebra stress relaxation and creep properties in ovariectomized rats with osteoporosis[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2011,15(26):4829-4832. |
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| Authors: | Zhang Qiao Zhang Zhong-jun Li Xin-ying |
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| Institution: | Zhang Qiao1,Zhang Zhong-jun2,Li Xin-ying11China-Japan Union Hospital of Jilin University,Changchun 130031,Jilin Province,China,2Department of Basic,Air Force Aviation University of Chinese PLA,Changchun 130022 |
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| Abstract: | BACKGROUND:For the prevention and treatment of osteoporosis,it is necessary to understand the relationships of the creep and stress relaxation of the spine with time in ovariectomized rats.OBJECTIVE:To observe the osteoporosis effects on the viscoelastic properties of load-bearing bone of ovariectomized female rats.METHODS:Forty-four Wistar female rats were divided into control and osteoporosis model groups.Rats in the model group were ovariectomized at 0 week.Stress relaxation trial with 1%/s strain rate a... |
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