小剂量孕激素治疗未破裂卵泡黄素化综合征的疗效研究

目的：研究小剂量孕激素治疗未破裂卵泡黄素化综合征的临床疗效。方法：选择2014年1月～2015年12月在我院进行诊治的未破裂卵泡黄素化综合征患者82例，随机分为观察组与对照组，每组各41例。观察组采用黄体酮和人绒毛膜促性腺激素治疗，对照组采用人绒毛膜促性腺激素治疗。B超监测排卵，观察患者受孕情况，检测雌二醇、孕酮和促黄体生成素水平，用彩色多普勒超声诊断仪检测卵泡发育侧卵巢动脉血流阻力指数。结果：观察组的有效率为85.37%，明显高于对照组的63.41%；注射后30h，观察组的孕酮水平明显升高，雌二醇和促黄体生成素无明显变化，对照组的雌二醇、孕酮和促黄体生成素均无明显变化；观察组的妊娠率为60.98%，排卵率为68.29%，均明显高于对照组；注射药物48h 后，观察组的卵巢动脉血流阻力指数明显低于对照组。结论：小剂量孕激素能提高未破裂卵泡黄素化综合征患者的妊娠率和排卵率，降低卵巢动脉血流阻力指数，具有重要的临床应用价值。

Curative effect of small dose of progesterone on luteinized unruptured follicle syndrome

Objective To investigate the curative effect of small dose of progesterone on luteinized unruptured follicle syndrome. Methods Selected 82 cases of patients with luteinized unruptured follicle syndrome who were treated in our hospital from January 2014 to December 2015, divided into two groups randomly, 41 cases in observation group, 41 cases in control group. The observation group was treated with progesterone and human chorionic gonadotropin, control group was treated with human chorionic gonadotropin. The conception and ovulation were observed, the level of estradiol, progesterone and luteinizing hormone were detected, using color doppler ultrasonic diagnostic instrument to detect the ovary blood flow resistance index. Results The effective rate of observation group was 85.37%, significantly higher than the control group 63.41%; 30 h after injection, the progesterone level of observation group was obviously increased, estradiol and luteinizing hormone had no significant change, the estradiol, progesterone and luteinizing hormone of control group had no significant change; the pregnancy rate of observation group was 60.98%, the ovulation rate was 68.29%, signifi-cantly higher than the control group; the ovary blood flow resistance index of observation group was significantly lower than the control group. Conclusion Small dose of progesterone can improve ovulation rate and pregnancy rate in patients with luteinized unruptured follicle syndrome, and reduce the ovary blood flow resistance index, has high clinical value.