低分子肝素钙早期干预防治呼吸衰竭患者凝血功能异常的临床研究

目的：探讨肝素早期干预防治呼吸衰竭患者凝血功能异常的临床疗效。方法：112例呼吸衰竭患者以数字表法随机分为观察组（n=56）与对照组（n=56），对照组给予常规治疗，观察组在对照组基础上加用低分子肝素钙治疗，对比两组患者血气指标、凝血功能及临床疗效。结果：治疗后观察组 PaO2、PaCO2、pH、PLT、D-dimer、PT、APTT 以及对照组 PaO2、pH、PLT、D-dimer、APTT 均明显好转，且治疗后观察组 PaO2、PaCO2、pH、PLT、D-dimer、PT、APTT 均显著优于对照组；观察组有效率为89.3%，显著高于对照组的66.1%。结论：低分子肝素钙能够有效改善呼吸衰竭患者凝血功能，降低血栓形成发生率，提高治疗有效率，改善患者预后。

Clinical Study of LMWH Early Application in prevention and cure of Abnormal Coagulation Function in the Patients with Respiratory Failure

Objective To discuss the clinical effects of heparin early application in prevention and cure of abnormal coagu-lation function in the patients with respiratory failure. Methods 112 patients with respiratory failure were randomly divided into the observation group (n=56) and the control group (n=56), the control group were given conventional therapy, and the obser-vation group were treated with LMWH based on the control group, then the blood gas indexes, blood coagulation function, clini-cal effect were contrasted between the two groups. Results After tha treatment, PaO2, PaCO2, pH, PLT, D-dimer, PT, APTT in the observation group and PaO2, pH, PLT, D-dimer, APTT in the control group were significantly better than before, and PaO2, PaCO2, pH, PLT, D-dimer, PT, APTT in the observation group were significantly better than the control group after the treat-ment; the effective rate was 89.3% in the observation group, significantly higher than 66.1% in the control group. Conclusion LMWH early application can effectively improve the coagulation function, reduce the incidence of thrombosis, improve the ef-ficiency of treatment, improve the prognosis in the patients with respiratory failure.