阿瑞匹坦联合托烷司琼、地塞米松预防顺铂化疗后呕吐的临床观察

目的：观察阿瑞匹坦联合托烷司琼、地塞米松预防含顺铂化疗方案引起呕吐的疗效及不良反应。方法：将76例使用含顺铂化疗方案的肺癌病人随机分为2组，对照组38例化疗过程中使用托烷司琼、地塞米松预防性止呕，观察组38例化疗过程中使用阿瑞匹坦联合托烷司琼、地塞米松预防性止呕。观察比较两组患者用药后急性期呕吐、延迟期呕吐的有效控制率及不良反应发生率。结果：观察组化疗引起的急性期呕吐及延迟期呕吐的有效控制率高于对照组。两组间不良反应比较无统计学意义。结论：阿瑞匹坦联合托烷司琼、地塞米松能有效预防含顺铂化疗方案引起的急性期及延迟期呕吐，不良反应可耐受。

Clinical Observation of Aprepitant Combined with Tropisetron and Dexamethasone in the Prevention of Vomiting Induced by Cisplatin Chemotherapy

Objective To observe the curative effect and adverse effect of aprepitant combined with tropisetron and dex-amethasone in the prevention of vomiting induced by cisplatin chemotherapy. Methods 76 lung cancer patients undergoing chemotherapy regimen including cisplatin were rando mLy divided into two groups. 38 patients in the control group were given tropisetron and dexamethasone, and 38 patients in the experimental group were given aprepitant combined with tropisetron and dexamethasone. The antiemetic effects in acute period and delay period and adverse effects were compared between the two groups. Results The antiemetic effect of the experiment group was better than the control group in the acute period and delay period. There were no statistical difference in the main adverse effects between the two groups. Conclusion Aprepitant com-bined with tropisetron and dexamethasone can effectively prevent vomiting induced by cisplatin chemotherapy in the acute pe-riod and delay period, with tolerable adverse effect.