Hp 感染伴消化性溃疡患儿的最佳治疗方案的探讨

目的：通过对 Hp 感染伴消化性溃疡患儿的治疗方案进行比较，为临床治疗提供依据。方法：选择2013年1月~2015年1月我院收治的 Hp 感染伴消化性溃疡儿童患者共80例，按照随机数字表法随机分成观察组（40例，给予奥美拉唑+阿莫西林+甲硝唑治疗）和对照组（40例，给予雷尼替丁+阿莫西林+甲硝唑治疗），治疗4w 后比较两组患者溃疡愈合情况、Hp 根除情况、血清前列腺素 E2（PGE2）和上皮细胞生长因子（EGF）的水平。结果：观察组和对照组患者总有效率分别为97.5％和87.5％，差异有统计学意义。观察组患者 Hp 根除率（85.00％）显著高于和对照组（62.50％），差异有统计学意义。观察组患者 Hp 根除时间显著低于和对照组，差异有统计学意义。治疗后，观察组 PGE2和 EGF 水平均高于对照组，差异有统计学意义。治疗后 PGE2和 EGF 水平均较治疗前升高，差异有统计学意义。结论：奥美拉唑、阿莫西林和甲硝唑联合治疗 Hp 感染伴消化性溃疡患儿，有较好的临床疗效和Hp 根除率，可以改善患者临床症状和粘膜修复，值得推广应用。

The best treatment method exploring on pediatric patients with peptic ulcer and Hp infection

Objective By comparing the different treatment methods on children with peptic ulcer infected with Hp, to pro-vide evidence for clinical treatment. Methods 80 pediatric patients with peptic ulcer and Hp infection from Jan. 2013 to Jan. 2015 were selected and divided into observation group (40 cases, treated by omeprazole + amoxicillin + metronidazole) and control group (40 cases, treated by ranitidine + amoxicillin + metronidazole), indicators of ulcer healing, Hp eradication, the serum prostaglandin E2 (PGE2) and epidermal growth factor (EGF) levels were compared after four weeks’treatment. Results The total effective rate in observation group and control group were 97.5% and 87.5% respectively, the difference was statisti-cally significance; Hp eradication rate of in observation group (85.00%) was significantly higher than that in the control group (62.50%), the difference was statistically significant. Hp eradication time in observation group were significantly lower than the control group, the difference was statistically significant. After treatment, PGE2 and EGF levels in observation group were high-er, the difference was statistically significant. PGE2 and EGF levels increased after treatment, the difference was statistically significant. Conclusion The combination therapy ofomeprazole, amoxicillin and metronidazole on peptic ulcer children with Hp infection, have better clinical efficacy and Hp eradication rate, can improve clinical symptoms and mucosal repair , should be widely applied.