Chemoprotective effects of Ulva lactuca (green seaweed) aqueous‐ethanolic extract against subchronic exposure to benzo(a)pyrene by CYP1A1 inhibition in mice |
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Authors: | Livan Delgado‐Roche Idania Rodeiro Mario Riera Jos Alfredo Herrera Ivonilce Venturi Yasnay Hernndez Gisselle Fernndez Carlos Luis Prez Juan Carlos Rodriguez Miguel David Fernndez Ivones Hernndez‐Balmaseda Julio Raul Fernndez Fernando Mesta Miriam Teresa Paz |
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Institution: | Livan Delgado‐Roche,Idania Rodeiro,Mario Riera,José Alfredo Herrera,Ivonilce Venturi,Yasnay Hernández,Gisselle Fernández,Carlos Luis Pérez,Juan Carlos Rodriguez,Miguel David Fernández,Ivones Hernández‐Balmaseda,Julio Raul Fernández,Fernando Mesta,Miriam Teresa Paz |
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Abstract: | The protective effect of the supplementation with an aqueous‐ethanolic extract obtained from Ulva lactuca (Delile) green seaweed on benzoa] pyrene‐induced damage in mice was evaluated. Animals were treated with oral doses of U. lactuca extract (100 and 400 mg/kg) for 9 weeks. They were exposed to 50 mg/kg of oral doses of benzo(a)pyrene starting from the second week and up to the fifth week. Groups treated with benzo(a)pyrene only (second to fifth weeks), sunflower oil (vehicle, 9 weeks), or U. lactuca extract (100 and 400 mg/kg, 9 weeks) were also included in the study. The treatment with 400 mg/kg of the extract ameliorated the oxidative damage, decreased IL‐1β and TNF‐α levels, and favorably regulated the antioxidant defenses compared with benzo(a)pyrene‐exposed group. The benzo(a)pyrene‐induced DNA damage was also reduced, as it was evidenced by the lower micronucleus formation in U. lactuca extract‐supplemented animals. The extract protected the hepatic tissue, and it reduced the liver activity/expression of CYP1A1. These results altogether suggested a chemoprotective effect of U. lactuca extract against benzo(a)pyrene‐induced‐toxicity in mice, probably associated with an inhibitory effect of carcinogen bioactivation. |
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Keywords: | antigenotoxic benzo(a)pyrene chemoprotection CYP1A1 green alga Ulva lactuca |
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