| 间充质干细胞来源外泌体在氧化应激损伤中的研究进展 |
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| 引用本文： | 翟骁,王一然,朱明向,王奇金. 间充质干细胞来源外泌体在氧化应激损伤中的研究进展[J]. 第二军医大学学报, 2018, 39(7): 716-721 |
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| 作者姓名： | 翟骁 王一然 朱明向 王奇金 |
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| 作者单位： | 1. 海军军医大学(第二军医大学)长海医院脊柱外科, 上海 200433;2. 海军军医大学(第二军医大学)基础医学院学员三大队, 上海 200433;3. 海军军医大学(第二军医大学)长海医院内分泌科, 上海 200433*通信作者 |
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| 基金项目： | 国家自然科学基金面上项目（81670741）,国家自然科学基金青年项目（81701199）,长海医院“1255”学科建设计划科研创新探索项目（CH125541900）. |
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| 摘 要： | 氧化应激损伤是导致疾病的一个重要因素。间充质干细胞来源外泌体（MSC-exo）含有多种蛋白质、脂质、编码RNA及非编码RNA,可通过多种途径减轻机体的氧化应激损伤,促进受损的组织细胞修复再生,因此MSC-exo在氧化应激所致疾病的治疗中有巨大的发展潜力。本文对MSC-exo在减轻氧化应激导致的心血管损伤、肺组织损伤、肾脏损伤、肝细胞损伤等方面的研究进展作一综述。
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| 关 键 词： | 间充质干细胞 外泌体 氧化性应激 损伤修复 |
| 收稿时间： | 2018-02-09 |
| 修稿时间： | 2018-06-21 |
Research progress of mesenchymal stem cell-derived exosomes in oxidative stress injury |
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| ZHAI Xiao,WANG Yi-ran,ZHU Ming-xiang and WANG Qi-jin. Research progress of mesenchymal stem cell-derived exosomes in oxidative stress injury[J]. Former Academic Journal of Second Military Medical University, 2018, 39(7): 716-721 |
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| Authors: | ZHAI Xiao WANG Yi-ran ZHU Ming-xiang WANG Qi-jin |
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| Affiliation: | 1. Department of Spine Surgery, Changhai Hospital, Navy Medical University(Second Military Medical University), Shanghai 200433, China;2. The Third Student Team, College of Basic Medical Sciences, Navy Medical University(Second Military Medical University), Shanghai 200433, China;3. Department of Endocrinology, Changhai Hospital, Navy Medical University(Second Military Medical University), Shanghai 200433, China*Corresponding author |
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| Abstract: | Oxidative stress damage is known to be a major factor leading to many diseases. Mesenchymal stem cell-derived exosomes (MSC-exos) are enriched with various proteins, lipids, coding RNAs and non-coding RNAs, and alleviate oxidative stress damage and stimulate the regeneration response of damaged tissues and cells. MSC-exos hold a great potential for the treatment of diseases caused by oxidative stress. In this review, we summarized the research progress of MSC-exos in cardiovascular injury, lung injury, kidney injury and liver cell injury caused by oxidative stress. |
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| Keywords: | mesenchymal stem cells exosomes oxdative stress damage repair |
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